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    Nadk1b NAD kinase 1b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nadk1bprovided by FlyBase
    Official Full Name
    NAD kinase 1bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053156
    Locus tag
    Dmel_CG33156
    See related
    AllianceGenome:FB:FBgn0053156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30063; CG33156; CG6152; Dmel\CG33156; NADK
    Summary
    Predicted to enable NAD+ kinase activity. Predicted to be involved in NADP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in ring gland. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nadk1b in Genome Data Viewer
    Location:
    50B1-50B1; 2-68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13548244..13553240, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9435749..9440745, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Lysine-CTT 1-10 Neighboring gene NAD kinase 1a Neighboring gene Roe1 Neighboring gene link

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis. Nakaoka T, et al. PLoS One, 2017. PMID 28257485, Free PMC Article
    2. Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glands. Moulos P, et al. BMC Genomics, 2018 Jul 13. PMID 30005604, Free PMC Article
    3. NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis. Xu M, et al. Cell Rep, 2021 Dec 28. PMID 34965438
    4. Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci. Talsma AD, et al. Mol Brain, 2014 Dec 5. PMID 25476251, Free PMC Article
    5. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results demonstrated that alas and CG33156 are indispensable for ecdysteroidogenesis.
      Title: Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NAD kinase 1b
    Names
    CG33156-PA
    CG33156-PB
    CG33156-PC
    CG33156-PE
    CG33156-PF
    NAD kinase
    Nadk1b-PA
    Nadk1b-PB
    Nadk1b-PC
    Nadk1b-PE
    Nadk1b-PF
    NP_001097302.1
    NP_788345.1
    NP_788346.1
    NP_788347.1
    NP_788348.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13548244..13553240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103832.3 → NP_001097302.1  NAD kinase 1b, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYC9, Q8IGP4
      Conserved Domains (1) summary
      cl01255
      Location:93 → 421
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. NM_176165.3 → NP_788345.1  NAD kinase 1b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRK7, Q8IGP4
      Related
      FBpp0086802
      Conserved Domains (1) summary
      cl01255
      Location:97 → 425
      DAGK_cat; Diacylglycerol kinase catalytic domain

    3. NM_176168.3 → NP_788348.1  NAD kinase 1b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGA7
      Related
      FBpp0086801
      Conserved Domains (1) summary
      cl01255
      Location:18 → 346
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. NM_176166.3 → NP_788346.1  NAD kinase 1b, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9F4, Q8IGP4
      Related
      FBpp0086803
      Conserved Domains (1) summary
      cl01255
      Location:133 → 461
      DAGK_cat; Diacylglycerol kinase catalytic domain

    5. NM_176167.3 → NP_788347.1  NAD kinase 1b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NK6, Q8IGP4
      Related
      FBpp0086804
      Conserved Domains (1) summary
      cl01255
      Location:96 → 424
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9F4 A1Z9F4
    A8DYC9 A8DYC9
    Q7JRK7 Q7JRK7
    Q86NK6 Q86NK6
    Q8IGA7 Q8IGA7
    Q8IGP4 Q8IGP4

    Gene LinkOut

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