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    Kap-alpha3 karyopherin alpha3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kap-alpha3provided by FlyBase
    Official Full Name
    karyopherin alpha3provided by FlyBase
    Primary source
    FLYBASE:FBgn0027338
    Locus tag
    Dmel_CG9423
    See related
    AllianceGenome:FB:FBgn0027338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0335/13; alphaKap3; CG9423; Dalpha3; dimpalpha3; dKap-alpha3; Dmel\CG9423; Imp alpha-3; imp alpha3; Imp alpha3; imp-a3; imp-alpha3; Imp-alpha3; impalpha3; Impalpha3; IMPalpha3; Kap alpha3; Kap-?3; KAP-ALPHA3; Kapalpha3; kpn-alpha3; Kpn-alpha3; Kpna3; l(3)S033513
    Summary
    Enables Notch binding activity and myosin binding activity. Involved in protein import into nucleus and response to UV. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut; eye photoreceptor cell; and ganglia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3) and KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kap-alpha3 in Genome Data Viewer
    Location:
    85D25-85D25; 3-48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9574484..9577733, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5400206..5403455, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Son RNA binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of karyopherin-alpha3 from Drosophila through its interaction with the nuclear localization sequence of germ cell-less protein. Dockendorff TC, et al. Biol Chem, 1999 Nov. PMID 10614818
    2. Identification of a classical bipartite nuclear localization signal in the Drosophila TEA/ATTS protein scalloped. Magico AC, et al. PLoS One, 2011. PMID 21731746, Free PMC Article
    3. Patterns of importin-alpha expression during Drosophila spermatogenesis. Giarrè M, et al. J Struct Biol, 2002 Oct-Dec. PMID 12490175
    4. Evolution of the metazoan-specific importin alpha gene family. Mason DA, et al. J Mol Evol, 2009 Apr. PMID 19308634
    5. Nicotinic acetylcholine receptors of Drosophila: three subunits encoded by genomically linked genes can co-assemble into the same receptor complex. Chamaon K, et al. J Neurochem, 2002 Jan. PMID 11796753

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of DnaJ-1 potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 also leads to reduced toxicity from pathogenic CACNA1A
      Title: DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6.
    2. These results reveal that the nuclear transport of Notch intracellular domain (Notch-ICD)is mediated by the canonical Importin-alpha3/Importin-beta transport pathway.
      Title: The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation.
    3. Data show that Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
      Title: Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
    4. each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
      Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    karyopherin alpha3
    Names
    CG9423-PA
    CG9423-PB
    CG9423-PC
    CG9423-PD
    Importin-alpha3
    Kap-alpha3-PA
    Kap-alpha3-PB
    Kap-alpha3-PC
    Kap-alpha3-PD
    dImportin-alpha3
    importin a3
    importin alpha
    importin alpha-3
    importin alpha3
    karyopherin
    karyopherin a3
    karyopherin alpha4
    karyopherin-alpha3
    karyopherin-alpha4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9574484..9577733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176437.2 → NP_788614.1  karyopherin alpha3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76522, Q9V455
      Related
      FBpp0081586
      Conserved Domains (5) summary
      COG5064
      Location:8 → 500
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:236 → 350
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:7 → 88
      IBB; Importin beta binding domain
      pfam16186
      Location:442 → 485
      Arm_3; Atypical Arm repeat
      sd00043
      Location:239 → 264
      ARM; armadillo repeat [structural motif]

    2. NM_169296.3 → NP_731378.1  karyopherin alpha3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76522, Q9V455
      Related
      FBpp0081585
      Conserved Domains (5) summary
      COG5064
      Location:8 → 500
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:236 → 350
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:7 → 88
      IBB; Importin beta binding domain
      pfam16186
      Location:442 → 485
      Arm_3; Atypical Arm repeat
      sd00043
      Location:239 → 264
      ARM; armadillo repeat [structural motif]

    3. NM_169295.3 → NP_731377.1  karyopherin alpha3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76522, Q9V455
      Related
      FBpp0081584
      Conserved Domains (5) summary
      COG5064
      Location:8 → 500
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:236 → 350
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:7 → 88
      IBB; Importin beta binding domain
      pfam16186
      Location:442 → 485
      Arm_3; Atypical Arm repeat
      sd00043
      Location:239 → 264
      ARM; armadillo repeat [structural motif]

    4. NM_001170101.1 → NP_001163572.1  karyopherin alpha3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76522, Q9V455
      Conserved Domains (5) summary
      COG5064
      Location:8 → 500
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:236 → 350
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:7 → 88
      IBB; Importin beta binding domain
      pfam16186
      Location:442 → 485
      Arm_3; Atypical Arm repeat
      sd00043
      Location:239 → 264
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76522 O76522
    Q9UB78 Q9UB78
    Q9V455 Q9V455

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