ttv tout-velu [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ttvprovided by FlyBase
Official Full Name: tout-veluprovided by FlyBase
Primary source: FLYBASE:FBgn0265974
Locus tag: Dmel_CG10117
See related: AllianceGenome:FB:FBgn0265974
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10117; dExt1; DEXT1; Dmel\CG10117; Ext1; EXT1; l(2)00681; l(2)05282; l(2)k00115; l(2)k03617; l(2)SH0631; l(2)SH2 0631; P1.15; Ttv
Summary: Enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in several processes, including germ cell migration; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and heparin biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Part of EXT1-EXT2 complex. Is expressed in organism. Human ortholog(s) of this gene implicated in chondrosarcoma and hereditary multiple exostoses. Orthologous to several human genes including EXT1 (exostosin glycosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51A7-51B4; 2-72 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14526267..14587917)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10413772..10475422)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hEXT1 gene was able to rescue a ttv null mutant to adulthood and restore glycosaminoglycan biosynthesis.
Title: Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu.
A novel role for toutvelu (ttv), a regulator of heparan sulfate proteoglycan biosynthesis during germ cell migration.
Title: toutvelu, a regulator of heparan sulfate proteoglycan biosynthesis, controls guidance cues for germ-cell migration.
Results suggest that all three Drosophila EXT proteins -- tout-velu, brother of tout-velu, and sister of tout-velu -- are required for the biosynthesis of heparan sulfate proteoglycans, and for the gradient formation of morphogens.
Title: Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 14537144-14537202 mobile_element_type = transposon:INE-1{}5641

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosaminoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of EXT1-EXT2 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tout-velu

Names: CG10117-PA; CG10117-PB; CG10117-PC; CG10117-PD; Tout-velu; lethal (2) SH0631; tout velour; tout velu; tout-velo; toutvelu; ttv-PA; ttv-PB; ttv-PC; ttv-PD

NP_001260971.1

EC 2.4.-.-

EC 2.4.1.17

EC 2.4.1.224

EC 2.4.1.225

NP_001260972.1

EC 2.4.-.-

EC 2.4.1.17

EC 2.4.1.224

EC 2.4.1.225

NP_001356963.1

EC 2.4.-.-

EC 2.4.1.17

EC 2.4.1.224

EC 2.4.1.225

NP_477231.1

EC 2.4.-.-

EC 2.4.1.17

EC 2.4.1.224

EC 2.4.1.225

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14526267..14587917

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274042.1 → NP_001260971.1 tout-velu, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260971.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76796, Q5BI21, Q9V730

UniProtKB/TrEMBL

A0A0B4KER9

Conserved Domains (2) summary

pfam03016
Location:102 → 393

Exostosin; Exostosin family

pfam09258
Location:477 → 733

Glyco_transf_64; Glycosyl transferase family 64 domain
NM_001369957.1 → NP_001356963.1 tout-velu, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4P7VB75

Conserved Domains (2) summary

pfam03016
Location:102 → 393

Exostosin; Exostosin family

pfam09258
Location:477 → 737

Glyco_transf_64; Glycosyl transferase family 64 domain
NM_057883.3 → NP_477231.1 tout-velu, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477231.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76796, Q5BI21, Q9V730

UniProtKB/TrEMBL

A0A0B4KER9

Related

FBpp0086624

Conserved Domains (2) summary

pfam03016
Location:102 → 393

Exostosin; Exostosin family

pfam09258
Location:477 → 733

Glyco_transf_64; Glycosyl transferase family 64 domain
NM_001274043.1 → NP_001260972.1 tout-velu, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260972.1

Status: REVIEWED

UniProtKB/TrEMBL

D5SHU8

Conserved Domains (1) summary

pfam09258
Location:16 → 272

Glyco_transf_64; Glycosyl transferase family 64 domain