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    heph hephaestus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hephprovided by FlyBase
    Official Full Name
    hephaestusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011224
    Locus tag
    Dmel_CG31000
    See related
    AllianceGenome:FB:FBgn0011224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2094; CG2290; CG31000; Dmel\CG31000; dmPTB; DmPTB; dPTB; ema; Heph; HEPH; Hephaestus; hnRNP I; l(3)03429; l(3)j11B9; ptb; Ptb; PTB
    Summary
    Enables mRNA 3'-UTR binding activity and mRNA regulatory element binding translation repressor activity. Involved in germ cell development; imaginal disc-derived wing morphogenesis; and negative regulation of oskar mRNA translation. Located in cytoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including CNS glial cell; adult brain cell body rind; epithelium; ganglia; and germline cell. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1); PTBP2 (polypyrimidine tract binding protein 2); and PTBP3 (polypyrimidine tract binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See heph in Genome Data Viewer
    Location:
    100D3-100E2; 3-103 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31846987..32015520, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27672709..27841242, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 100F Neighboring gene Ferrochelatase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45556 Neighboring gene pseudo Neighboring gene Poseidon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lineage-specific expression of polypyrimidine tract binding protein (PTB) in Drosophila embryos. Davis MB, et al. Mech Dev, 2002 Feb. PMID 11804786
    2. Drosophila polypyrimidine tract-binding protein is necessary for spermatid individualization. Robida M, et al. Proc Natl Acad Sci U S A, 2010 Jul 13. PMID 20616016, Free PMC Article
    3. Single-molecule imaging of transcriptionally coupled and uncoupled splicing. Vargas DY, et al. Cell, 2011 Nov 23. PMID 22118462, Free PMC Article
    4. Chromosome-specific maturation of the epigenome in the Drosophila male germline. Anderson JT, et al. Elife, 2023 Nov 30. PMID 38032818, Free PMC Article
    5. Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo. Wesley CS, et al. PLoS One, 2011. PMID 21750738, Free PMC Article

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
      Title: Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
    2. Results identified Heph as an RNA-binding protein that specifically binds to the polo upstream sequence element RNA and demonstrate that Heph has a function in polo mRNA 3'-end formation and expression, which are impaired in heph mutants.
      Title: Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster.
    3. This study provides the first comprehensive list of genes misregulated in vivo in the heph2 mutant in Drosophila.
      Title: High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis.
    4. Drosophila PTB regulates dorso-ventral patterning genes in embryos.
      Title: Drosophila polypyrimidine tract-binding protein (DmPTB) regulates dorso-ventral patterning genes in embryos.
    5. Heph is required in the germline for efficient Grk signalling to the somatic follicle cells during dorso-ventral patterning.
      Title: Drosophila Hephaestus/polypyrimidine tract binding protein is required for dorso-ventral patterning and regulation of signalling between the germline and soma.
    6. Data raise the possibility that the Drosophila embryo is divided into zones of different PTB and Notch activities based on whether or not they are linked to actin regulation.
      Title: Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo.
    7. a cytoplasmic form of PTB can associate with oskar mRNA and repress its translation, suggesting that nuclear recruitment of PTB to oskar complexes is not required for its regulatory function
      Title: Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.
    8. genetic analysis of polypyrimidine tract binding protein function in any organism and evidence that such proteins may be involved in the Notch signalling pathway
      Title: Hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster.
    9. Data show that polypyrimidine-tract binding protein appears to be a particularly potent downstream target of the sex-determination pathway in the male germline, since it can regulate multiple mRNAs.
      Title: Drosophila polypyrimidine-tract binding protein (PTB) functions specifically in the male germline.
    10. expression is patterned in the early embryo and occurs in specific mesodermal and neuronal lineages as well as in the imaginal discs and adult germline
      Title: Lineage-specific expression of polypyrimidine tract binding protein (PTB) in Drosophila embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c31897206-31887801 mobile_element_type = transposon:HB{}1605
    • Loc: c31968982-31968714 mobile_element_type = transposon:INE-1{}5306
    • Loc: c31972305-31971913 mobile_element_type = transposon:INE-1{}5305
    • Loc: c31996294-31996236 mobile_element_type = transposon:INE-1{}3999
    • Loc: c32006274-32005992 mobile_element_type = transposon:INE-1{}4005
    • Loc: c32008160-32008101 mobile_element_type = transposon:INE-1{}4009
    • Loc: c32009317-32009239 mobile_element_type = transposon:INE-1{}4013

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of oskar mRNA translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hephaestus
    Names
    CG31000-PA
    CG31000-PB
    CG31000-PC
    CG31000-PD
    CG31000-PE
    CG31000-PF
    CG31000-PG
    CG31000-PH
    CG31000-PI
    CG31000-PJ
    CG31000-PK
    CG31000-PL
    CG31000-PM
    CG31000-PN
    CG31000-PO
    CG31000-PP
    CG31000-PQ
    CG31000-PR
    CG31000-PS
    CG31000-PT
    CG31000-PU
    CG31000-PV
    CG31000-PW
    CG31000-PY
    CG31000-PZ
    ectopic margin
    heph-PA
    heph-PB
    heph-PC
    heph-PD
    heph-PE
    heph-PF
    heph-PG
    heph-PH
    heph-PI
    heph-PJ
    heph-PK
    heph-PL
    heph-PM
    heph-PN
    heph-PO
    heph-PP
    heph-PQ
    heph-PR
    heph-PS
    heph-PT
    heph-PU
    heph-PV
    heph-PW
    heph-PY
    heph-PZ
    heterogeneous nuclear RibonucleoProtein I
    polypyrimidine tract binding protein
    polypyrimidine tract-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31846987..32015520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104524.3 → NP_001097994.1  hephaestus, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097994.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    2. NM_001170322.2 → NP_001163793.1  hephaestus, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF8, Q8T0H5
      Conserved Domains (5) summary
      cd12423
      Location:388 → 461
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:505 → 580
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:47 → 127
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:195 → 290
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:45 → 581
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    3. NM_001104522.3 → NP_001097992.1  hephaestus, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRI1, Q8T0H5
      Conserved Domains (5) summary
      cd12423
      Location:429 → 502
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:546 → 621
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:88 → 168
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:236 → 331
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:86 → 622
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    4. NM_176603.3 → NP_788780.1  hephaestus, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95UI6
      Related
      FBpp0085240
      Conserved Domains (5) summary
      cd12423
      Location:596 → 669
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:713 → 788
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:255 → 335
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:403 → 498
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:253 → 789
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    5. NM_001170316.2 → NP_001163787.1  hephaestus, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95UI6
      Conserved Domains (5) summary
      cd12423
      Location:596 → 669
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:713 → 788
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:255 → 335
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:403 → 498
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:253 → 789
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    6. NM_176602.3 → NP_788779.1  hephaestus, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085245
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    7. NM_176596.3 → NP_788773.1  hephaestus, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085241
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    8. NM_176601.3 → NP_788778.1  hephaestus, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085244
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    9. NM_176600.3 → NP_788777.1  hephaestus, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085243
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    10. NM_001260469.2 → NP_001247398.1  hephaestus, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6P4
      Conserved Domains (5) summary
      cd12423
      Location:606 → 679
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:723 → 798
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:269 → 349
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:417 → 512
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:267 → 799
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    11. NM_170582.4 → NP_733461.2  hephaestus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733461.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085238
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    12. NM_176597.3 → NP_788774.1  hephaestus, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085242
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    13. NM_176599.2 → NP_788776.2  hephaestus, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788776.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRS7, Q8T0H5
      Related
      FBpp0085246
      Conserved Domains (5) summary
      cd12423
      Location:422 → 495
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:539 → 614
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:81 → 161
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:229 → 324
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:79 → 615
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    14. NM_001170319.1 → NP_001163790.1  hephaestus, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95UI6
      Conserved Domains (5) summary
      cd12423
      Location:596 → 669
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:713 → 788
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:255 → 335
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:403 → 498
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:253 → 789
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    15. NM_001260470.1 → NP_001247399.1  hephaestus, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6W9
      Conserved Domains (5) summary
      cd12423
      Location:705 → 778
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:822 → 897
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:368 → 448
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:516 → 611
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:366 → 898
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    16. NM_176598.2 → NP_788775.1  hephaestus, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085247
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    17. NM_001170321.2 → NP_001163792.1  hephaestus, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF8, Q8T0H5
      Conserved Domains (5) summary
      cd12423
      Location:388 → 461
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:505 → 580
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:47 → 127
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:195 → 290
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:45 → 581
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    18. NM_001170320.2 → NP_001163791.1  hephaestus, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF8, Q8T0H5
      Conserved Domains (5) summary
      cd12423
      Location:388 → 461
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:505 → 580
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:47 → 127
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:195 → 290
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:45 → 581
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    19. NM_079964.3 → NP_524703.1  hephaestus, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF8, Q8T0H5
      Related
      FBpp0085239
      Conserved Domains (5) summary
      cd12423
      Location:388 → 461
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:505 → 580
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:47 → 127
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:195 → 290
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:45 → 581
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    20. NM_001300701.1 → NP_001287630.1  hephaestus, isoform Z [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287630.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHY1, Q8T0H5
      Conserved Domains (5) summary
      cd12423
      Location:411 → 484
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:528 → 603
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 604
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    21. NM_170581.2 → NP_733460.1  hephaestus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Related
      FBpp0085237
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    22. NM_001170317.2 → NP_001163788.1  hephaestus, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    23. NM_001170323.2 → NP_001163794.1  hephaestus, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF7, Q8T0H5, Q8WR53
      Conserved Domains (5) summary
      cd12423
      Location:415 → 488
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:532 → 607
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:74 → 154
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:222 → 317
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:72 → 608
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    24. NM_001104523.3 → NP_001097993.1  hephaestus, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3T7F7, Q7KES3
      Conserved Domains (5) summary
      cd12423
      Location:375 → 448
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:492 → 567
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12688
      Location:34 → 114
      RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:182 → 277
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:32 → 568
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    25. NM_001170318.2 → NP_001163789.1  hephaestus, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ45, Q3T7F7
      Conserved Domains (5) summary
      cd12423
      Location:300 → 373
      RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12425
      Location:417 → 492
      RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12693
      Location:107 → 202
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:1 → 493
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:1 → 39
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6P4 A0A0B4K6P4
    A0A0B4K6W9 A0A0B4K6W9
    A0A0B4LHY1 A0A0B4LHY1
    A8JRI1 A8JRI1
    E1JJ45 E1JJ45
    Q3T7F7 Q3T7F7
    Q7KES3 Q7KES3
    Q7KRS7 Q7KRS7
    Q8IMF8 Q8IMF8
    Q8MT11 Q8MT11
    Q8T0H5 Q8T0H5
    Q8WR53 Q8WR53
    Q95UI6 Q95UI6

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