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    wech wech [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wechprovided by FlyBase
    Official Full Name
    wechprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259745
    Locus tag
    Dmel_CG42396
    See related
    AllianceGenome:FB:FBgn0259745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1624; CG42396; Dmel\CG42396; dpld; Dpld; lin-41; Wech
    Summary
    Enables protein-macromolecule adaptor activity. Involved in instar larval development; muscle attachment; and regulation of cell-cell adhesion mediated by integrin. Located in muscle tendon junction. Is expressed in several structures, including CNS glial cell; epithelial cell; ganglia; head epidermis primordium; and sensory neurons. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wech in Genome Data Viewer
    Location:
    43C5-43C5; 2-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7478853..7489823, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3366358..3377328, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Aldehyde dehydrogenase type III Neighboring gene p47 Neighboring gene antisense RNA:CR43723 Neighboring gene Corepressor of Pangolin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mis-expression study of factors affecting Drosophila PNS cell identity. O'Farrell F, et al. Biochem Biophys Res Commun, 2008 Jun 13. PMID 18420029
    2. Regulation of hemocytes in Drosophila requires dappled cytochrome b5. Kleinhesselink K, et al. Biochem Genet, 2011 Jun. PMID 21279680, Free PMC Article
    3. Genetic mapping of the p47 (L.3.2) mutation in Drosophilamelanogaster. Cordes CN, et al. MicroPubl Biol, 2023. PMID 37799208, Free PMC Article
    4. Temporal control of bidirectional lipid-droplet motion in Drosophila depends on the ratio of kinesin-1 and its co-factor Halo. Arora GK, et al. J Cell Sci, 2016 Apr 1. PMID 26906417, Free PMC Article
    5. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Pasquinelli AE, et al. Nature, 2000 Nov 2. PMID 11081512

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show taht dpld seems to be miRNA regulated, suggesting that miRNAs represent an ancient mechanism of LIN-41 regulation.
      Title: Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subclade.
    2. String and dappled were identified as being important for the proper formation of adult external sensory (ES) organs.
      Title: A mis-expression study of factors affecting Drosophila PNS cell identity.
    3. Data suggest that Wech proteins are crucial and evolutionarily conserved regulators of the integrin-cytoskeleton link.
      Title: The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell-cell adhesion mediated by integrin IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wech
    Names
    CG42396-PA
    CG42396-PB
    CG42396-PC
    CG42396-PD
    CG42396-PE
    dappled
    wech-PA
    wech-PB
    wech-PC
    wech-PD
    wech-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7478853..7489823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165534.3 → NP_724568.1  wech, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724568.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
      Related
      FBpp0289359
      Conserved Domains (5) summary
      COG3391
      Location:527 → 740
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00021
      Location:187 → 224
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd14954
      Location:528 → 810
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      sd00039
      Location:603 → 640
      7WD40; WD40 repeat [structural motif]
      cl23765
      Location:232 → 343
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_001144142.3 → NP_001137614.1  wech, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137614.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
      Conserved Domains (5) summary
      COG3391
      Location:527 → 740
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00021
      Location:187 → 224
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd14954
      Location:528 → 810
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      sd00039
      Location:603 → 640
      7WD40; WD40 repeat [structural motif]
      cl23765
      Location:232 → 343
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. NM_080033.4 → NP_524772.2  wech, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524772.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
      Related
      FBpp0289357
      Conserved Domains (5) summary
      COG3391
      Location:527 → 740
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00021
      Location:187 → 224
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd14954
      Location:528 → 810
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      sd00039
      Location:603 → 640
      7WD40; WD40 repeat [structural motif]
      cl23765
      Location:232 → 343
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    4. NM_001144143.2 → NP_001137615.1  wech, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137615.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
      Conserved Domains (5) summary
      COG3391
      Location:527 → 740
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00021
      Location:187 → 224
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd14954
      Location:528 → 810
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      sd00039
      Location:603 → 640
      7WD40; WD40 repeat [structural motif]
      cl23765
      Location:232 → 343
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    5. NM_165533.3 → NP_724567.1  wech, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
      Related
      FBpp0289358
      Conserved Domains (5) summary
      COG3391
      Location:527 → 740
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00021
      Location:187 → 224
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd14954
      Location:528 → 810
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      sd00039
      Location:603 → 640
      7WD40; WD40 repeat [structural motif]
      cl23765
      Location:232 → 343
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4M2.2 Q9V4M2

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