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    Ect3 Ectoderm-expressed 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ect3provided by FlyBase
    Official Full Name
    Ectoderm-expressed 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0260746
    Locus tag
    Dmel_CG3132
    See related
    AllianceGenome:FB:FBgn0260746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    87A7-9/8; anon-87Ag; CG3132; Dmel\CG3132
    Summary
    Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be active in vacuole. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; head epidermis primordium; and midline glial cell. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to several human genes including GLB1L (galactosidase beta 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ect3 in Genome Data Viewer
    Location:
    87A4-87A4; 3-51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11999278..12003516)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7825000..7829238)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene midline fasciclin Neighboring gene Tachykinin Neighboring gene Kelch like family member 18 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene DDB1 and CUL4 associated factor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparison of midline and tracheal gene regulation during Drosophila development. Long SK, et al. PLoS One, 2014. PMID 24465586, Free PMC Article
    2. Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers. Pearson JC, et al. Development, 2016 Oct 15. PMID 27802137, Free PMC Article
    3. Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression. Pearson JC, et al. Dev Biol, 2014 Aug 15. PMID 24854999, Free PMC Article
    4. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Glover DM, et al. Cell, 1995 Apr 7. PMID 7720077
    5. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ectoderm-expressed 3
    Names
    CG3132-PA
    Ect3-PA
    anon-87Ag
    beta-galactosidase
    NP_650142.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11999278..12003516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141885.3 → NP_650142.1  Ectoderm-expressed 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGE7
      Related
      FBpp0081961
      Conserved Domains (2) summary
      pfam01301
      Location:32 → 350
      Glyco_hydro_35; Glycosyl hydrolases family 35
      pfam13364
      Location:576 → 616
      BetaGal_dom4_5; Beta-galactosidase jelly roll domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGE7 Q9VGE7

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