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    CG42813 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43276, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42813provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261995
    Locus tag
    Dmel_CG42813
    See related
    AllianceGenome:FB:FBgn0261995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31063; CG6001; Dmel\CG42813; Mth1; Nudix
    Old locus tag
    Dmel_CG31063
    Summary
    Predicted to enable UDP-sugar diphosphatase activity. Predicted to be involved in nucleoside phosphate metabolic process and ribose phosphate metabolic process. Is expressed in adult head and adult heart. Orthologous to human NUDT14 (nudix hydrolase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42813 in Genome Data Viewer
    Location:
    97E10-97E10; 3-92 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27227070..27228561, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23053162..23054244, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Serrate Neighboring gene long non-coding RNA:CR34006 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of double MutT/Nudix domain-containing proteins: similar domain architectures from independent gene duplication-fusion events. Lin J, et al. J Genet Genomics, 2009 Oct. PMID 19840758
    2. Genetic identification and characterization of three genes that prevent accumulation of oxidative DNA damage in Drosophila adult tissues. Okumura K, et al. DNA Repair (Amst), 2019 Jun. PMID 30947023
    3. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100
    4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-sugar diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribose phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42813-PA
    CG42813-PB
    NP_001303547.1
    NP_733202.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27227070..27228561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316618.1 → NP_001303547.1  uncharacterized protein Dmel_CG42813, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB73, Q9VB64
      Conserved Domains (1) summary
      cd03424
      Location:41 → 205
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

    2. NM_170323.2 → NP_733202.2  uncharacterized protein Dmel_CG42813, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733202.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB73, Q9VB64
      Conserved Domains (1) summary
      cd03424
      Location:41 → 205
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB64 Q9VB64

    Gene LinkOut

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