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    CG8654 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8654provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034479
    Locus tag
    Dmel_CG8654
    See related
    AllianceGenome:FB:FBgn0034479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8654
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; antennal anlage; and central brain anlage. Orthologous to human SLC22A13 (solute carrier family 22 member 13) and SLC22A14 (solute carrier family 22 member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8654 in Genome Data Viewer
    Location:
    56F4-56F4; 2-90 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19979242..19984895)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15866747..15872400)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Arginine-CCT 1-2 Neighboring gene transfer RNA:Arginine-CCT 1-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus Drosophila. Díaz-Castillo C, et al. PLoS Genet, 2012 Feb. PMID 22319453, Free PMC Article
    2. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
    3. Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Engelhart DC, et al. Int J Mol Sci, 2020 Mar 15. PMID 32183456, Free PMC Article
    4. Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? Foley BR, et al. Biol Lett, 2010 Feb 23. PMID 19692395, Free PMC Article
    5. Genes encoding novel secreted and transmembrane proteins are temporally and spatially regulated during Drosophila melanogaster embryogenesis. Zúñiga A, et al. BMC Biol, 2009 Sep 22. PMID 19772636, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8654-PA
    CG8654-PB
    CG8654-PC
    CG8654-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19979242..19984895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259513.2 → NP_001246442.1  uncharacterized protein Dmel_CG8654, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246442.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3M6
      Conserved Domains (2) summary
      cd06174
      Location:87 → 477
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00879
      Location:85 → 487
      SP; MFS transporter, sugar porter (SP) family

    2. NM_001299695.1 → NP_001286624.1  uncharacterized protein Dmel_CG8654, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3M6
      Conserved Domains (2) summary
      cd06174
      Location:87 → 477
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00879
      Location:85 → 487
      SP; MFS transporter, sugar porter (SP) family

    3. NM_137607.5 → NP_611451.1  uncharacterized protein Dmel_CG8654, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3M6
      Related
      FBpp0085642
      Conserved Domains (2) summary
      cd06174
      Location:87 → 477
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00879
      Location:85 → 487
      SP; MFS transporter, sugar porter (SP) family

    4. NM_001259512.2 → NP_001246441.1  uncharacterized protein Dmel_CG8654, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3M6
      Conserved Domains (2) summary
      cd06174
      Location:87 → 477
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00879
      Location:85 → 487
      SP; MFS transporter, sugar porter (SP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3M6 Q7K3M6

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