U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    frma fra mauro [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31464, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    frmaprovided by FlyBase
    Official Full Name
    fra mauroprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029769
    Locus tag
    Dmel_CG3239
    See related
    AllianceGenome:FB:FBgn0029769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH09377; CG3239; Dmel\CG3239; Nepl1
    Summary
    Involved in negative regulation of female receptivity, post-mating. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See frma in Genome Data Viewer
    Location:
    5A1-5A1; 1-12 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5493014..5496052, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5387047..5390085, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44471 Neighboring gene uncharacterized protein Neighboring gene Sex peptide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular evolution of the sex peptide network in Drosophila. McGeary MK, et al. J Evol Biol, 2020 May. PMID 31991034
    2. Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure. Tu Q, et al. Chemosphere, 2023 Jul. PMID 37080472
    3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    4. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Radyuk SN, et al. Mech Ageing Dev, 2012 Jun. PMID 22579812
    5. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    fra mauro
    Names
    CG3239-PF
    CG3239-PG
    Dmel_CG3239
    Neprilysin-like 1
    frma-PF
    frma-PG

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5493014..5496052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167038.2 → NP_726999.2  fra mauro, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726999.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3N8, Q8IRR7, Q95TX8, Q9W4B8
      Conserved Domains (1) summary
      cl14813
      Location:25 → 601
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    2. NM_131998.3 → NP_572226.2  fra mauro, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572226.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3N8, Q8IRR7, Q95TX8, Q9W4B8
      Conserved Domains (1) summary
      cl14813
      Location:25 → 601
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3N8 Q7K3N8
    Q9W4B8 Q9W4B8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous