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    tadr torn and diminished rhabdomeres [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tadrprovided by FlyBase
    Official Full Name
    torn and diminished rhabdomeresprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032911
    Locus tag
    Dmel_CG9264
    See related
    AllianceGenome:FB:FBgn0032911
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9264; Dmel\CG9264; Tadr; torn
    Summary
    Enables L-histidine transmembrane transporter activity. Involved in histidine transport. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tadr in Genome Data Viewer
    Location:
    39A1-39A1; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21075405..21081053)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21075405..21081053)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Integrin betanu subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila. Han Y, et al. Elife, 2022 Mar 1. PMID 35229720, Free PMC Article
    2. A Closer Look at Histamine in Drosophila. Volonté C, et al. Int J Mol Sci, 2024 Apr 18. PMID 38674034, Free PMC Article
    3. Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila. Ni L, et al. J Neurosci, 2008 Dec 10. PMID 19074021, Free PMC Article
    4. Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster. Wang H, et al. Sci Rep, 2015 Oct 8. PMID 26446369, Free PMC Article
    5. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Koh TW, et al. Neuron, 2004 Jul 22. PMID 15260956

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we report a gene named tadr (for torn and diminished rhabdomeres), which, when mutated, leads to photoreceptor degeneration
      Title: Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-histidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables basic amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in histidine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    torn and diminished rhabdomeres
    Names
    CG9264-PC
    CG9264-PD
    tadr-PC
    tadr-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21075405..21081053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136238.3 → NP_610082.2  torn and diminished rhabdomeres, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610082.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRK8, Q9VIG5
      Conserved Domains (1) summary
      TIGR00906
      Location:5 → 209
      2A0303; cationic amino acid transport permease

    2. NM_165354.2 → NP_724308.2  torn and diminished rhabdomeres, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724308.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRK8, Q9I7L6
      Conserved Domains (1) summary
      TIGR00906
      Location:5 → 209
      2A0303; cationic amino acid transport permease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JRK8 Q7JRK8
    Q8MQS0 Q8MQS0
    Q9I7L6 Q9I7L6
    Q9VIG5 Q9VIG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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