Orc2 Origin recognition complex subunit 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Orc2provided by FlyBase
Official Full Name: Origin recognition complex subunit 2provided by FlyBase
Primary source: FLYBASE:FBgn0015270
Locus tag: Dmel_CG3041
See related: AllianceGenome:FB:FBgn0015270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3041; Dmel\CG3041; DmORC 2; DmOrc2; DmORC2; DmOrc2p; dOrc2; fs(3)293; fs(3)293-19; k43; l(3)88Ab; l(3)A5; l(3)dsl5; l(3)k43; l(3)K43; l(3)SG44; ORC; Orc-2; orc2; ORC2; Orc2p; rDmORC
Summary: Enables chromatin binding activity. Involved in DNA metabolic process; mitotic chromosome condensation; and mitotic spindle organization. Located in alpha-heterochromatin and nucleus. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including CNS glial cell; Malpighian tubule primordium; antennal anlage; ganglia; and head epidermis primordium. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13964885..13967075)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9790607..9792797)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Cessation of mitotic cyclin-dependent kinase activity is essential for binding of the DmOrc proteins to chromosomes.
Title: Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity.
The results, taken together, demonstrate that the orc2 gene is under the control of DREF pathway.
Title: Transcriptional regulation of the Drosophila orc2 gene by the DREF pathway.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated DNA replication	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eggshell chorion gene amplification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in alpha-heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear origin of replication recognition complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of origin recognition complex	IEA Inferred from Electronic Annotation more info

Names: CG3041-PA; Orc2-PA; lethal(3)88Ab; origin recognition complex; origin recognition complex 2

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