sip1 septin interacting protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sip1provided by FlyBase
Official Full Name: septin interacting protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0024191
Locus tag: Dmel_CG7238
See related: AllianceGenome:FB:FBgn0024191
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH11690; CG7238; Dmel\CG7238; GH11690; Sip1
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in spliceosomal complex disassembly. Located in cytoplasm. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism and spermatozoon. Orthologous to human TFIP11 (tuftelin interacting protein 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5721051..5723944)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5721051..5723944)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain.
Title: Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain.
a model was developed in which SIP1 normally regulates NHE2 activity and luminal pH, ultimately leading to uric acid stone formation
Title: Targeted renal knockdown of Na(+)/H(+) exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in spliceosomal complex disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal complex disassembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U2-type post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain