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    GlnRS Glutaminyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GlnRSprovided by FlyBase
    Official Full Name
    Glutaminyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027090
    Locus tag
    Dmel_CG10506
    See related
    AllianceGenome:FB:FBgn0027090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aast-g1n; Aats-gln; BcDNA:GH11673; CG10506; Dmel\CG10506; dQARS; l(3)05461; qars; QRS
    Summary
    Predicted to enable glutamine-tRNA ligase activity. Involved in dendrite morphogenesis. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head and organism. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GlnRS in Genome Data Viewer
    Location:
    96C8-96C8; 3-87 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25263267..25265721, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21088989..21091443, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46099 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45214 Neighboring gene RIO kinase 2 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
    2. Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. Chihara T, et al. Nat Neurosci, 2007 Jul. PMID 17529987
    3. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    4. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
    5. MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure. Wu Z, et al. Mol Cell, 2019 Aug 22. PMID 31378462, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutaminyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutaminyl-tRNA synthetase
    Names
    CG10506-PA
    GlnRS-PA
    NP_524841.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25263267..25265721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080102.5 → NP_524841.1  Glutaminyl-tRNA synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBU3, Q9Y105
      Related
      FBpp0084240
      Conserved Domains (1) summary
      PLN02859
      Location:10 → 777
      PLN02859; glutamine-tRNA ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y105.1 Q9Y105

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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