Rm62 Rm62 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rm62provided by FlyBase
Official Full Name: Rm62provided by FlyBase
Primary source: FLYBASE:FBgn0003261
Locus tag: Dmel_CG10279
See related: AllianceGenome:FB:FBgn0003261
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4136; CG10279; Dmel\CG10279; dmP68; Dmp68; DmRH8; l(3)01086; l(3)j3D2; l(3)j3D5; l(3)rG338; l(3)s5196; Lip; p68; rm62; RM62
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Involved in regulation of defense response to virus; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA-mediated heterochromatin formation. Located in nucleus and polytene chromosome puff. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; gonad; and imaginal disc. Used to study alcohol use disorder. Orthologous to human DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83D1-83D2; 3-47.5 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (6000426..6008579, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1826148..1834301, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Through an RNAi screen in Drosophila cells, study identified Rm62 as an anti-RVFV helicase gene. Rm62 is also essential for resistance to RVFV infection in vivo, as RVFV-challenged Rm62-deficient flies showed increased viral replication and mortality.
Title: Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.
RNA helicase interacts with the well-characterized histone methyltransferase SU(VAR)3-9 via its N-terminus, which provides a potential mechanism for the targeting of H3K9 methylation to highly regulated genes.
Title: The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster.
Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos
Title: Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos.
have isolated a dFMR1-associated complex that includes two ribosomal proteins, L5 and L11, along with 5S RNA. The dFMR1 complex also contains Argonaute2 (AGO2) and a Drosophila homolog of p68 RNA helicase (Dmp68)
Title: A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rm62

Names: CG10279-PA; CG10279-PB; CG10279-PC; CG10279-PD; CG10279-PE; CG10279-PF; CG10279-PH; CG10279-PI; CG10279-PJ; CG10279-PK; CG10279-PL; CG10279-PM; Lighten-up; Rm62-PA; Rm62-PB; Rm62-PC; Rm62-PD; Rm62-PE; Rm62-PF; Rm62-PH; Rm62-PI; Rm62-PJ; Rm62-PK; Rm62-PL; Rm62-PM; helicase p62; lighten up; p68 RNA helicase

NP_001163528.1

EC 3.6.4.13

NP_001189182.1

EC 3.6.4.13

NP_001246938.1

EC 3.6.4.13

NP_001246939.1

EC 3.6.4.13

NP_001246940.1

EC 3.6.4.13

NP_001246941.1

EC 3.6.4.13

NP_524243.2

EC 3.6.4.13

NP_731031.1

EC 3.6.4.13

NP_731032.1

EC 3.6.4.13

NP_731033.1

EC 3.6.4.13

NP_731034.1

EC 3.6.4.13

NP_731035.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

6000426..6008579 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260010.1 → NP_001246939.1 Rm62, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246939.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6T7

Conserved Domains (3) summary

smart00487
Location:152 → 359

DEXDc; DEAD-like helicases superfamily

cd00079
Location:355 → 453

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:139 → 344

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001202253.2 → NP_001189182.1 Rm62, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189182.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAE4

Conserved Domains (3) summary

PTZ00424
Location:139 → 515

PTZ00424; helicase 45; Provisional

cd00079
Location:358 → 492

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:142 → 347

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001260012.1 → NP_001246941.1 Rm62, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246941.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6K1

Conserved Domains (3) summary

smart00487
Location:152 → 359

DEXDc; DEAD-like helicases superfamily

cd00079
Location:355 → 450

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:139 → 344

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001260009.1 → NP_001246938.1 Rm62, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246938.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K624

Conserved Domains (3) summary

smart00487
Location:152 → 359

DEXDc; DEAD-like helicases superfamily

cd00079
Location:355 → 450

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:139 → 344

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_169118.1 → NP_731031.1 Rm62, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731031.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ68

Related

FBpp0078299, FBtr0078650

Conserved Domains (3) summary

PTZ00424
Location:136 → 512

PTZ00424; helicase 45; Provisional

cd00079
Location:355 → 489

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:139 → 344

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001260011.1 → NP_001246940.1 Rm62, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246940.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6A3

Conserved Domains (3) summary

smart00487
Location:152 → 359

DEXDc; DEAD-like helicases superfamily

cd00079
Location:355 → 450

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:139 → 344

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_169120.1 → NP_731033.1 Rm62, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731033.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P19109

Related

FBpp0078298, FBtr0078649

Conserved Domains (3) summary

PTZ00424
Location:139 → 515

PTZ00424; helicase 45; Provisional

cd00079
Location:358 → 492

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:142 → 347

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001170057.1 → NP_001163528.1 Rm62, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163528.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ68

Conserved Domains (3) summary

PTZ00424
Location:136 → 512

PTZ00424; helicase 45; Provisional

cd00079
Location:355 → 489

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:139 → 344

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_079519.2 → NP_524243.2 Rm62, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524243.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2H1, P19109, Q6AWN9, Q8IGL7, Q95TB8, Q9I7P5, Q9VNK4

Related

FBpp0078301, FBtr0078652

Conserved Domains (3) summary

PTZ00424
Location:280 → 656

PTZ00424; helicase 45; Provisional

cd00079
Location:499 → 633

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:283 → 488

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_169122.1 → NP_731035.2 Rm62, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731035.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P19109

Related

FBpp0078300, FBtr0078651

Conserved Domains (3) summary

PTZ00424
Location:139 → 515

PTZ00424; helicase 45; Provisional

cd00079
Location:358 → 492

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:142 → 347

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_169119.3 → NP_731032.1 Rm62, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731032.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAE4

Related

FBpp0078302

Conserved Domains (3) summary

PTZ00424
Location:139 → 515

PTZ00424; helicase 45; Provisional

cd00079
Location:358 → 492

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:142 → 347

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_169121.2 → NP_731034.1 Rm62, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731034.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P19109

Related

FBpp0078303

Conserved Domains (3) summary

PTZ00424
Location:139 → 515

PTZ00424; helicase 45; Provisional

cd00079
Location:358 → 492

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:142 → 347

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K624		A0A0B4K624
A0A0B4K6A3		A0A0B4K6A3
A0A0B4K6K1		A0A0B4K6K1
A0A0B4K6T7		A0A0B4K6T7
C7LAE4		C7LAE4
E1JJ68		E1JJ68
P19109.3		P19109
Q5LK30		Q5LK30