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    Vha26 Vacuolar H[+]-ATPase 26kD subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vha26provided by FlyBase
    Official Full Name
    Vacuolar H[+]-ATPase 26kD subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283535
    Locus tag
    Dmel_CG1088
    See related
    AllianceGenome:FB:FBgn0283535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-83Bb; ATP6V1E1; BcDNA.GH03683; BcDNA:GH03683; CG1088; chr3R:1419698..1419836; Dmel\CG1088; oak-gall; okg; vATPase; vha26; VhaE
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in apical protein localization and terminal branching, open tracheal system. Located in plasma membrane. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; epithelial tube; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Orthologous to several human genes including ATP6V1E2 (ATPase H+ transporting V1 subunit E2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha26 in Genome Data Viewer
    Location:
    83B4-83B4; 3-47.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5591763..5595356)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1417485..1421078)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU4:25F-C137 Neighboring gene DNA polymerase zeta subunit 2 Neighboring gene noisette Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene krasavietz

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effective delivery and selective insecticidal activity of double-stranded RNA via complexation with diblock copolymer varies with polymer block composition. Pugsley CE, et al. Pest Manag Sci, 2024 Feb. PMID 37759365
    2. Characterisation of vha26, the Drosophila gene for a 26 kDa E-subunit of the vacuolar ATPase. Guo Y, et al. Biochim Biophys Acta, 1996 Aug 14. PMID 8765087
    3. Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts. Rose PP, et al. Cell Host Microbe, 2011 Aug 18. PMID 21843867, Free PMC Article
    4. Engineered Flock House Virus for Targeted Gene Suppression Through RNAi in Fruit Flies (Drosophila melanogaster) in Vitro and in Vivo. Taning CNT, et al. Front Physiol, 2018. PMID 30018564, Free PMC Article
    5. Ingested double-stranded RNAs can act as species-specific insecticides. Whyard S, et al. Insect Biochem Mol Biol, 2009 Nov. PMID 19815067

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system HMP PubMed 
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in terminal branching, open tracheal system HMP PubMed 
    involved_in terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of proton-transporting two-sector ATPase complex, catalytic domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+]-ATPase 26kD subunit
    Names
    CG1088-PA
    CG1088-PB
    CG1088-PC
    E subunit
    Vha26-PA
    Vha26-PB
    Vha26-PC
    oak gall
    vacuolar ATP synthase subunit E
    vacuolar H+ATPase subunit E
    vacuolar H[+]-ATPase 26 kD E subunit
    vacuolar H[+]-ATPase 26kD E subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5591763..5595356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300253.1 → NP_001287182.1  vacuolar H[+]-ATPase 26kD subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54611, Q0KIB6, Q9V3K4
      UniProtKB/TrEMBL
      A0A0B4LGS4
      Conserved Domains (2) summary
      COG1390
      Location:9 → 217
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam01991
      Location:18 → 216
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    2. NM_169073.2 → NP_730957.1  vacuolar H[+]-ATPase 26kD subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54611, Q0KIB6, Q9V3K4
      UniProtKB/TrEMBL
      A0A0B4LGS4
      Related
      FBpp0078350
      Conserved Domains (2) summary
      COG1390
      Location:9 → 217
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam01991
      Location:18 → 216
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    3. NM_079513.3 → NP_524237.1  vacuolar H[+]-ATPase 26kD subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54611, Q0KIB6, Q9V3K4
      UniProtKB/TrEMBL
      A0A0B4LGS4
      Related
      FBpp0078349
      Conserved Domains (2) summary
      COG1390
      Location:9 → 217
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam01991
      Location:18 → 216
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGS4 A0A0B4LGS4
    P54611.1 P54611

    Gene LinkOut

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