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    pdgy pudgy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdgyprovided by FlyBase
    Official Full Name
    pudgyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027601
    Locus tag
    Dmel_CG9009
    See related
    AllianceGenome:FB:FBgn0027601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02901; CG9009; Dmel\CG9009; Pdgy
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Involved in fatty-acyl-CoA biosynthetic process; long-chain fatty acid metabolic process; and triglyceride catabolic process. Located in mitochondrion. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; epithelium; fat body; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pdgy in Genome Data Viewer
    Location:
    13A1-13A1; 1-49 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14933670..14953532, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14827703..14847565, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Flotillin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44831 Neighboring gene uncharacterized protein Neighboring gene ether a go-go

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The acyl-CoA Synthetase, pudgy, Promotes Sleep and Is Required for the Homeostatic Response to Sleep Deprivation. Thimgan MS, et al. Front Endocrinol (Lausanne), 2018. PMID 30186232, Free PMC Article
    2. Insulin signaling regulates fatty acid catabolism at the level of CoA activation. Xu X, et al. PLoS Genet, 2012 Jan. PMID 22275878, Free PMC Article
    3. Selective sweep in the Flotillin-2 region of European Drosophila melanogaster. Werzner A, et al. PLoS One, 2013. PMID 23437190, Free PMC Article
    4. The microRNA miR-33 is a pleiotropic regulator of metabolic and developmental processes in Drosophila melanogaster. Clerbaux LA, et al. Dev Dyn, 2021 Nov. PMID 33840153
    5. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. Jünger MA, et al. J Biol, 2003. PMID 12908874, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty-acyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pudgy
    Names
    CG9009-PA
    CG9009-PB
    CG9009-PC
    CG9009-PD
    long chain fatty acid CoA ligase
    pdgy-PA
    pdgy-PB
    pdgy-PC
    pdgy-PD
    NP_001188590.1
    NP_001245673.1
    NP_001285257.1
    NP_572988.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14933670..14953532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201661.2 → NP_001188590.1  pudgy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXZ8, Q9Y158
      Conserved Domains (2) summary
      cd05911
      Location:99 → 587
      Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
      COG0318
      Location:77 → 595
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

    2. NM_001298328.1 → NP_001285257.1  pudgy, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXZ8, Q9Y158
      Conserved Domains (2) summary
      cd05911
      Location:99 → 587
      Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
      COG0318
      Location:77 → 595
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

    3. NM_001258744.1 → NP_001245673.1  pudgy, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXZ8, Q9Y158
      Conserved Domains (2) summary
      cd05911
      Location:99 → 587
      Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
      COG0318
      Location:77 → 595
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

    4. NM_132760.5 → NP_572988.1  pudgy, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXZ8, Q9Y158
      Related
      FBpp0073789
      Conserved Domains (2) summary
      cd05911
      Location:99 → 587
      Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
      COG0318
      Location:77 → 595
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXZ8 Q9VXZ8

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