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    Ythdc1 YTH domain containing 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ythdc1provided by FlyBase
    Official Full Name
    YTH domain containing 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027616
    Locus tag
    Dmel_CG12076
    See related
    AllianceGenome:FB:FBgn0027616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH01918; CG12076; Dmel\CG12076; dYT521-B; YT521; YT521-B; ythdc; Ythdc
    Summary
    Enables N6-methyladenosine-containing RNA reader activity; mRNA binding activity; and pre-mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and sex determination. Located in nucleus. Is expressed in larval central nervous system and ventral neurectoderm. Orthologous to human YTHDC1 (YTH N6-methyladenosine RNA binding protein C1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ythdc1 in Genome Data Viewer
    Location:
    63D2-63D2; 3-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3370451..3374170, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3370451..3374170, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene karst Neighboring gene Drosomycin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila. Kan L, et al. Nat Commun, 2021 Mar 5. PMID 33674589, Free PMC Article
    2. The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders. Angelova MT, et al. Front Bioeng Biotechnol, 2018. PMID 29707539, Free PMC Article
    3. Cell type-specific regulation of m(6) A modified RNAs in the aging Drosophila brain. Perlegos AE, et al. Aging Cell, 2024 Mar. PMID 38205931, Free PMC Article
    4. The RNA-binding protein Nab2 regulates levels of the RhoGEF Trio to govern axon and dendrite morphology. Lancaster CL, et al. Mol Biol Cell, 2024 Aug 1. PMID 38985523, Free PMC Article
    5. Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila. Worpenberg L, et al. EMBO J, 2021 Feb 15. PMID 33428246, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. m(6)A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.
      Title: m(6)A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N6-methyladenosine-containing RNA reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    YTH domain containing 1
    Names
    CG12076-PA
    CG12076-PB
    YT521-B
    Ythdc1-PA
    Ythdc1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3370451..3374170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139554.4 → NP_647811.2  YTH domain containing 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647811.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IH35, Q8IRD2, Q9VZQ1, Q9Y172
      Related
      FBpp0072940
      Conserved Domains (1) summary
      pfam04146
      Location:254 → 392
      YTH; YT521-B-like domain

    2. NM_168029.2 → NP_728876.1  YTH domain containing 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRD2
      Related
      FBpp0072941
      Conserved Domains (1) summary
      pfam04146
      Location:243 → 380
      YTH; YT521-B-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZQ1.2 Q9VZQ1

    Gene LinkOut

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