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    OtopLb Otopetrin-like b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OtopLbprovided by FlyBase
    Official Full Name
    Otopetrin-like bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031514
    Locus tag
    Dmel_CG3332
    See related
    AllianceGenome:FB:FBgn0031514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3332; Dmel\CG3332; dmOTOPLb; dm_OtopLb; otoplb; OtopLB
    Summary
    Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be active in membrane. Is expressed in embryonic anal pad; embryonic large intestine; and embryonic rectum. Orthologous to human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See OtopLb in Genome Data Viewer
    Location:
    23E1-23E1; 2-9 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3275800..3280534, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3275800..3280534, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44484 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44485 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Otopetrin-like b
    Names
    CG3332-PA
    CG3332-PB
    CG3332-PC
    CG3332-PD
    OtopLb-PA
    OtopLb-PB
    OtopLb-PC
    OtopLb-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3275800..3280534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164531.2 → NP_722888.1  Otopetrin-like b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ02
      Related
      FBpp0077295
      Conserved Domains (1) summary
      pfam03189
      Location:162 → 610
      Otopetrin; Otopetrin

    2. NM_001298652.1 → NP_001285581.1  Otopetrin-like b, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J8I0
      Conserved Domains (1) summary
      pfam03189
      Location:180 → 628
      Otopetrin; Otopetrin

    3. NM_001298651.1 → NP_001285580.1  Otopetrin-like b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD17
      Conserved Domains (1) summary
      pfam03189
      Location:329 → 777
      Otopetrin; Otopetrin

    4. NM_134914.3 → NP_608758.1  Otopetrin-like b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U85, Q9VQN3
      Related
      FBpp0077296
      Conserved Domains (1) summary
      pfam03189
      Location:330 → 778
      Otopetrin; Otopetrin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQ02 Q8IQ02
    Q9VQN3 Q9VQN3
    X2J8I0 X2J8I0
    X2JD17 X2JD17

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