Mpv17 Mitochondrial inner membrane protein MPV17 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mpv17provided by FlyBase
Official Full Name: Mitochondrial inner membrane protein MPV17provided by FlyBase
Primary source: FLYBASE:FBgn0039930
Locus tag: Dmel_CG11077
See related: AllianceGenome:FB:FBgn0039930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11077; Dmel\CG11077; dMpv17; MPV17; PMP22
Summary: Enables monoatomic ion channel activity and uridine transmembrane transporter activity. Involved in monoatomic ion transmembrane transport and uridine transmembrane transport. Is active in mitochondrial inner membrane. Is expressed in adult head; embryonic/larval garland cell; and organism. Used to study Charcot-Marie-Tooth disease type 2EE; mitochondrial DNA depletion syndrome; and mitochondrial DNA depletion syndrome 6. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2EE and mitochondrial DNA depletion syndrome 6. Orthologous to human MPV17 (mitochondrial inner membrane protein MPV17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (1028675..1029361, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (1049301..1049987, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in homeostatic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial genome maintenance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitochondrial DNA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in uridine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain