PIP4K Phosphatidylinositol 5-phosphate 4-kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PIP4Kprovided by FlyBase
Official Full Name: Phosphatidylinositol 5-phosphate 4-kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0039924
Locus tag: Dmel_CG17471
See related: AllianceGenome:FB:FBgn0039924
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17471; Dmel\CG17471; dPIP4K; DPIP4K; PIP5K 102E
Summary: Enables 1-phosphatidylinositol-5-phosphate 4-kinase activity and mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation of clathrin-dependent endocytosis; phosphatidylinositol phosphate biosynthetic process; and regulation of signal transduction. Located in cytosol; early endosome; and plasma membrane. Is expressed in adult abdomen; adult head; adult thorax; and eye. Orthologous to several human genes including PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102F8-102F8; 4-0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (1192419..1196848, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (1213045..1217474, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rh1(also known as NinaE))-trafficking defect in PIP4K-depleted cells could be suppressed by downregulating Rab5 function or by selectively reconstituting PIP4K in the PI3P-enriched early endosomal compartment of photoreceptors
Title: Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c1194701-1194282 mobile_element_type = transposon:1360{}4077
Loc: c1194876-1194732 mobile_element_type = transposon:1360{}5480

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 5-phosphate 4-kinase

Names: CG17471-PA; CG17471-PB; PIP4K-PA; PIP4K-PB

NP_001033805.1

EC 2.7.1.149

EC 2.7.1.68

NP_001033806.1

EC 2.7.1.149

EC 2.7.1.68

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

1192419..1196848 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038716.2 → NP_001033805.1 phosphatidylinositol 5-phosphate 4-kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033805.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SXX1

Conserved Domains (1) summary

cl02572
Location:32 → 403

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
NM_001038717.2 → NP_001033806.1 phosphatidylinositol 5-phosphate 4-kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033806.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SXX1

Conserved Domains (1) summary

cl02572
Location:32 → 403

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...