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    Ttc1 Tetratricopeptide repeat domain 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41993, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc1provided by FlyBase
    Official Full Name
    Tetratricopeptide repeat domain 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038428
    Locus tag
    Dmel_CG14894
    See related
    AllianceGenome:FB:FBgn0038428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14894; Dmel\CG14894; dTtc1
    Summary
    Located in cytosol. Is expressed in embryonic/larval midgut and organism. Orthologous to human TTC1 (tetratricopeptide repeat domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ttc1 in Genome Data Viewer
    Location:
    89B16-89B16; 3-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16441843..16443007, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12267565..12268729, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene endosomal maturation defective Neighboring gene uncharacterized protein Neighboring gene Pak3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dTtc1, a conserved tetratricopeptide repeat protein, is required for maturation of Drosophila egg chambers via its role in stabilizing electron transport chain components. Neiswender H, et al. Front Cell Dev Biol, 2023. PMID 37333987, Free PMC Article
    2. The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Matzkin LM, et al. Genetics, 2005 Jul. PMID 15781702, Free PMC Article
    3. Expression of Mst89B and CG31287 is Needed for Effective Sperm Storage and Egg Fertilization in Drosophila. Grewal G, et al. Cells, 2021 Feb 1. PMID 33535499, Free PMC Article
    4. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Cannavò E, et al. Nature, 2017 Jan 19. PMID 28024300
    5. Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina. Thanawala SU, et al. Dev Cell, 2013 Apr 15. PMID 23597484, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetratricopeptide repeat domain 1
    Names
    CG14894-PA
    CG14894-PB
    Ttc1-PA
    Ttc1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16441843..16443007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275707.1 → NP_001262636.1  tetratricopeptide repeat domain 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEV3
      Conserved Domains (4) summary
      smart00028
      Location:167 → 198
      TPR; Tetratricopeptide repeats
      sd00006
      Location:94 → 122
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:133 → 166
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:93 → 164
      TPR_11; TPR repeat

    2. NM_142286.3 → NP_650543.1  tetratricopeptide repeat domain 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEV3
      Related
      FBpp0082765
      Conserved Domains (4) summary
      smart00028
      Location:167 → 198
      TPR; Tetratricopeptide repeats
      sd00006
      Location:94 → 122
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:133 → 166
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:93 → 164
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEV3 Q9VEV3

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