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    ClC-a Chloride channel-a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41428, updated on 17-Dec-2024

    Summary

    Official Symbol
    ClC-aprovided by FlyBase
    Official Full Name
    Chloride channel-aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051116
    Locus tag
    Dmel_CG31116
    See related
    AllianceGenome:FB:FBgn0051116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14726; CG31116; CG6942; CLC-2; Clc-a; DmClC-2; DmClC-a; DmClCa; Dmel\CG31116; FBgn0037951
    Summary
    Enables chloride channel activity. Involved in chloride transport and water transport. Located in apical plasma membrane and basal plasma membrane. Is expressed in several structures, including Malpighian tubule Type II cell; adult head; embryonic/larval midgut; ganglia; and glial cell. Used to study myopathy. Human ortholog(s) of this gene implicated in several diseases, including idiopathic generalized epilepsy 11; myotonia congenita (multiple); primary hyperaldosteronism; renal tubular transport disease (multiple); and sensorineural hearing loss. Orthologous to several human genes including CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ClC-a in Genome Data Viewer
    Location:
    86F8-86F8; 3-51 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11797244..11813207, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7622966..7638929, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pruning defect 1 Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene glorund Neighboring gene Cytochrome c oxidase subunit 5A Neighboring gene Kynurenine aminotransferase

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    mobile_element

    • Loc: c11807783-11807583 mobile_element_type = transposon:INE-1{}2915

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chloride transmembrane transport PubMed 
    involved_in chloride transport  
    involved_in chloride transport  
    involved_in chloride transport  
    involved_in renal water homeostasis PubMed 
    involved_in renal water transport PubMed 
    involved_in transepithelial chloride transport PubMed 
    involved_in transepithelial water transport PubMed 
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    located_in apical plasma membrane PubMed 
    located_in basal plasma membrane PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    chloride channel-a
    Names
    CG31116-PA
    CG31116-PC
    CG31116-PD
    CG31116-PF
    CG31116-PG
    CG31116-PH
    CG31116-PI
    ClC-a-PA
    ClC-a-PC
    ClC-a-PD
    ClC-a-PF
    ClC-a-PG
    ClC-a-PH
    ClC-a-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11797244..11813207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104281.2 → NP_001097751.2  chloride channel-a, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097751.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Conserved Domains (3) summary
      cd03683
      Location:123 → 598
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:844 → 921
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:179 → 567
      Voltage_CLC; Voltage gated chloride channel
    2. NM_001170121.1 → NP_001163592.1  chloride channel-a, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Conserved Domains (3) summary
      cd03683
      Location:123 → 598
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:952 → 1048
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:179 → 567
      Voltage_CLC; Voltage gated chloride channel
    3. NM_001275558.1 → NP_001262487.1  chloride channel-a, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGV4
    4. NM_001104282.3 → NP_001097752.1  chloride channel-a, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUP0
      Conserved Domains (3) summary
      cd03683
      Location:171 → 646
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:905 → 969
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
      cl15354
      Location:659 → 718
      CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily
    5. NM_176462.2 → NP_788639.1  chloride channel-a, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4VCL3, A8JQX8, A8JQX9, E1JIJ0, Q7YU63, Q8INJ7, Q8MRL4, Q9VGH7, Q9VGH8
      Related
      FBpp0082002
      Conserved Domains (3) summary
      cd03683
      Location:171 → 646
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:1000 → 1096
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:227 → 615
      Voltage_CLC; Voltage gated chloride channel
    6. NM_169431.3 → NP_731634.2  chloride channel-a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731634.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0082001
      Conserved Domains (3) summary
      cd03683
      Location:154 → 629
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:875 → 952
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:210 → 598
      Voltage_CLC; Voltage gated chloride channel
    7. NM_169432.3 → NP_731635.2  chloride channel-a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731635.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0082000
      Conserved Domains (3) summary
      cd03683
      Location:154 → 629
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:983 → 1079
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:210 → 598
      Voltage_CLC; Voltage gated chloride channel
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