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    nac neuronally altered carbohydrate [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nacprovided by FlyBase
    Official Full Name
    neuronally altered carbohydrateprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265351
    Locus tag
    Dmel_CG9620
    See related
    AllianceGenome:FB:FBgn0265351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9620; Dmel\CG9620; gfr; Gfr; Nac
    Summary
    Enables GDP-fucose transmembrane transporter activity. Involved in several processes, including GDP-fucose import into Golgi lumen; N-glycan fucosylation; and grooming behavior. Located in Golgi apparatus and Golgi-associated vesicle. Is expressed in adult head. Used to study congenital disorder of glycosylation type II. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIc. Orthologous to human SLC35C1 (solute carrier family 35 member C1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nac in Genome Data Viewer
    Location:
    84F10-84F10; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8302686..8304023, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4128408..4129745, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene suppressor-of-G2-allele-of-skp1 Neighboring gene mir-4918 stem loop Neighboring gene tex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster. Lühn K, et al. Exp Cell Res, 2004 Dec 10. PMID 15530860
    2. The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter. Geisler C, et al. J Biol Chem, 2012 Aug 24. PMID 22745127, Free PMC Article
    3. A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). Katz F, et al. EMBO J, 1988 Nov. PMID 2463162, Free PMC Article
    4. Neural-specific carbohydrate moiety shared by many surface glycoproteins in Drosophila and grasshopper embryos. Snow PM, et al. J Neurosci, 1987 Dec. PMID 3320283, Free PMC Article
    5. Characterization of nervana, a Drosophila melanogaster neuron-specific glycoprotein antigen recognized by anti-horseradish peroxidase antibodies. Sun B, et al. J Neurochem, 1995 Jul. PMID 7540667

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the nac(1) Gfr mutation produces a previously unrecognized general defect in N-glycan core fucosylation.
      Title: The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter.
    2. Data show that Gfr and Efr function redundantly in the O-fucosylation of Notch, although they had different localizations and nucleotide sugar transportation specificities.
      Title: Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.
    3. study gives experimental proof that the product of the in silico identified Drosophila gene CG9620 serves as a functional GDP-fucose transporter
      Title: Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables CMP-N-acetylneuraminate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-fucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-fucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-fucose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT enables GDP-mannose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables UDP-N-acetylgalactosamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables UDP-N-acetylglucosamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables UDP-galactose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables UDP-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables UDP-glucuronic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in CMP-N-acetylneuraminate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-fucose import into Golgi lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-fucose import into Golgi lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-fucose import into Golgi lumen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GDP-fucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in GDP-mannose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-glycan fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in UDP-N-acetylgalactosamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in UDP-N-acetylglucosamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in UDP-galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in UDP-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in UDP-glucuronic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronally altered carbohydrate
    Names
    CG9620-PA
    Gfr
    golgi GDP-fucose transporter
    nac-PA
    neurally altered carbohydrate
    neuronally-altered-carbohydrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8302686..8304023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141525.2 → NP_649782.1  neuronally altered carbohydrate [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YF6, Q9VHT4
      Related
      FBpp0081352
      Conserved Domains (1) summary
      pfam03151
      Location:16 → 281
      TPT; Triose-phosphate Transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHT4.1 Q9VHT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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