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    CG6951 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6951provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036959
    Locus tag
    Dmel_CG6951
    See related
    AllianceGenome:FB:FBgn0036959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.579; Dmel\CG6951
    Summary
    Predicted to enable dCMP deaminase activity. Predicted to be involved in cytidine deamination. Predicted to be active in cytoplasm. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6951 in Genome Data Viewer
    Location:
    77A3-77A4; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20241267..20245312)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20234367..20238412)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 3-3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Clathrin light chain Neighboring gene retinal degeneration C Neighboring gene antisense RNA:CR43876 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster. Bogaerts-Márquez M, et al. Mol Ecol, 2021 Feb. PMID 33350518, Free PMC Article
    2. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
    3. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dCMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dCMP deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6951-PA
    CG6951-PB
    NP_649197.1
    NP_730502.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20241267..20245312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168838.3 → NP_730502.1  uncharacterized protein Dmel_CG6951, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XF4, Q9VWA2
      UniProtKB/TrEMBL
      L7VG69
      Related
      FBpp0074597
      Conserved Domains (1) summary
      cd01286
      Location:29 → 164
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    2. NM_140940.3 → NP_649197.1  uncharacterized protein Dmel_CG6951, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649197.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XF4, Q9VWA2
      UniProtKB/TrEMBL
      L7VG69
      Related
      FBpp0074598
      Conserved Domains (1) summary
      cd01286
      Location:29 → 164
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWA2.1 Q9VWA2

    Gene LinkOut

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