AstC-R1 Allatostatin C receptor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AstC-R1provided by FlyBase
Official Full Name: Allatostatin C receptor 1provided by FlyBase
Primary source: FLYBASE:FBgn0036790
Locus tag: Dmel_CG7285
See related: AllianceGenome:FB:FBgn0036790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0131005.19; anon-WO0170980.79; anon-WO0170980.80; AstC R1; ASTC-R1; AstCR1; CG7285; Dmel\CG7285; Drostar1; drSTAR1; star1
Summary: Enables allatostatin receptor activity. Involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in adult head; adult pars intercerebralis; lamina monopolar neurons; and larval central nervous system. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to several human genes including SSTR1 (somatostatin receptor 1); SSTR2 (somatostatin receptor 2); and SSTR3 (somatostatin receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (18560258..18576326)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18553358..18569426)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drostar genes are required for visual information processing as well as endocrine regulation
Title: Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables allatostatin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables somatostatin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

Names: ASC-receptor; ASTC receptor 1; AstC-R1-PA; CG7285-PA; drosophila allatostatin C receptor 1

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