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    Ccn Ccn [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccnprovided by FlyBase
    Official Full Name
    Ccnprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052183
    Locus tag
    Dmel_CG32183
    See related
    AllianceGenome:FB:FBgn0052183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13735; CG13736; CG32183; dCCN; Dmel\CG32183
    Summary
    Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in cell adhesion; positive regulation of cell differentiation; and signal transduction. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in arthropathy; high grade glioma; and progressive pseudorheumatoid arthropathy of childhood. Orthologous to several human genes including CCN1 (cellular communication network factor 1); CCN2 (cellular communication network factor 2); and CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ccn in Genome Data Viewer
    Location:
    74F1-75A1; 3-45 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17690015..17748839)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17683115..17741939)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene CREB-regulated transcription coactivator Neighboring gene small non-coding RNA 641 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45976 Neighboring gene Chemosensory protein B 74a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adenosine deaminase-related growth factor B Neighboring gene Adenosine deaminase-related growth factor A Neighboring gene Adenosine deaminase-related growth factor A2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility. Catudio Garrett E, et al. Genetics, 2023 Mar 2. PMID 36602539, Free PMC Article
    2. A deficiency screen of the 3rd chromosome for dominant modifiers of the Drosophila ER integral membrane protein, Jagunal. Ascencio G, et al. G3 (Bethesda), 2023 Jul 5. PMID 36932646, Free PMC Article
    3. Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation. Trevino CE, et al. Fertil Steril, 2021 Sep. PMID 34016428, Free PMC Article
    4. Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior. Shorter J, et al. Proc Natl Acad Sci U S A, 2015 Jul 7. PMID 26100892, Free PMC Article
    5. Age-related ceRNA networks in adult Drosophila ageing. Yang D, et al. Front Genet, 2023. PMID 36926584, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 17730906-17731510 mobile_element_type = transposon:mdg1{}1023
    • Loc: 17731511-17737054 mobile_element_type = transposon:mdg1{}1611
    • Loc: 17737055-17738178 mobile_element_type = transposon:mdg1{}1025

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ccn
    Names
    CG32183-PB
    Ccn-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17690015..17748839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168744.2 → NP_730294.1  Ccn [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVK3
      Related
      FBpp0074951
      Conserved Domains (1) summary
      cl17735
      Location:41 → 104
      VWC; von Willebrand factor type C domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVK3 Q9VVK3

    Gene LinkOut

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