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    enc encore [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    encprovided by FlyBase
    Official Full Name
    encoreprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004875
    Locus tag
    Dmel_CG10847
    See related
    AllianceGenome:FB:FBgn0004875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BB129; CG10847; Dmel\CG10847; Enc; fs(3)63F-64A
    Summary
    Predicted to enable nucleic acid binding activity. Involved in cystoblast division and germarium-derived oocyte fate determination. Located in cytoplasm. Is expressed in adult head; germarium region 1; germline cell; and testis. Orthologous to human R3HDM1 (R3H domain containing 1); R3HDM2 (R3H domain containing 2); and ARPP21 (cAMP regulated phosphoprotein 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See enc in Genome Data Viewer
    Location:
    63F1-63F3; 3-9 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3818679..3842326)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3818679..3842326)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45034 Neighboring gene Succinyl-coenzyme A synthetase alpha subunit 1 Neighboring gene Accessory gland protein 63F Neighboring gene Red herring Neighboring gene Arrowhead Neighboring gene long non-coding RNA:CR45379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale mapping of transposable element insertion sites using digital encoding of sample identity. Gohl DM, et al. Genetics, 2014 Mar. PMID 24374352, Free PMC Article
    2. Encore, a gene required for the regulation of germ line mitosis and oocyte differentiation during Drosophila oogenesis. Hawkins NC, et al. Development, 1996 Jan. PMID 8565840
    3. Genetic screen identifies a requirement for SMN in mRNA localisation within the Drosophila oocyte. Aquilina B, et al. BMC Res Notes, 2018 Jun 13. PMID 29895323, Free PMC Article
    4. Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila. Hawkins NC, et al. Development, 1997 Dec. PMID 9428416
    5. Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance. Li Y, et al. Proc Natl Acad Sci U S A, 2009 Jun 9. PMID 19470484, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 3833792-3833977 mobile_element_type = transposon:pogo{}921

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line cyst formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oocyte karyosome formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    encore
    Names
    CG10847-PA
    CG10847-PB
    CG10847-PD
    CG10847-PE
    CG10847-PF
    CG10847-PG
    CG10847-PH
    enc-PA
    enc-PB
    enc-PD
    enc-PE
    enc-PF
    enc-PG
    enc-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3818679..3842326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206270.2 → NP_995992.1  encore, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX1
      Conserved Domains (2) summary
      cd02642
      Location:448 → 508
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:527 → 578
      SUZ; SUZ domain

    2. NM_001274447.1 → NP_001261376.1  encore, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH77
      Conserved Domains (2) summary
      cd02642
      Location:448 → 508
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:527 → 578
      SUZ; SUZ domain

    3. NM_001104027.2 → NP_001097497.1  encore, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097497.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNJ9
      Conserved Domains (2) summary
      cd02642
      Location:443 → 503
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:522 → 573
      SUZ; SUZ domain

    4. NM_001274449.1 → NP_001261378.1  encore, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE05
      Conserved Domains (2) summary
      cd02642
      Location:443 → 503
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:522 → 573
      SUZ; SUZ domain

    5. NM_080026.3 → NP_524765.2  encore, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524765.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JNK0, B6IDK9, Q5BIH9, Q7KV61, Q8MSX1, Q9NGQ6, Q9VZM1
      Related
      FBpp0073011
      Conserved Domains (2) summary
      cd02642
      Location:443 → 503
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:522 → 573
      SUZ; SUZ domain

    6. NM_001274448.1 → NP_001261377.1  encore, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBM2
      Conserved Domains (2) summary
      cd02642
      Location:304 → 364
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:383 → 434
      SUZ; SUZ domain

    7. NM_001104026.2 → NP_001097496.1  encore, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097496.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JNK0, B6IDK9, Q5BIH9, Q7KV61, Q8MSX1, Q9NGQ6, Q9VZM1
      Conserved Domains (2) summary
      cd02642
      Location:443 → 503
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:522 → 573
      SUZ; SUZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNJ9 A8JNJ9
    M9PBM2 M9PBM2
    M9PE05 M9PE05
    M9PH77 M9PH77
    Q8MSX1.2 Q8MSX1

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