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    Fatp3 Fatty acid transport protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fatp3provided by FlyBase
    Official Full Name
    Fatty acid transport protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0034999
    Locus tag
    Dmel_CG3394
    See related
    AllianceGenome:FB:FBgn0034999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg3394; CG3394; Dmel\CG3394
    Summary
    Predicted to enable long-chain fatty acid transmembrane transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval crystal cell; embryonic/larval posterior spiracle; and epithelium. Orthologous to human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fatp3 in Genome Data Viewer
    Location:
    60C6-60C6; 2-106 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24294097..24298111)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20181620..20185634)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nervy Neighboring gene mir-4985 stem loop Neighboring gene beta-Tubulin at 60D Neighboring gene long non-coding RNA:CR44810

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fatty acid transport proteins in disease: New insights from invertebrate models. Dourlen P, et al. Prog Lipid Res, 2015 Oct. PMID 26416577
    2. The negative elongation factor NELF promotes induced transcriptional response of Drosophila ecdysone-dependent genes. Mazina MY, et al. Sci Rep, 2021 Jan 8. PMID 33420323, Free PMC Article
    3. Proximity-dependent biotin labelling reveals CP190 as an EcR/Usp molecular partner. Mazina MY, et al. Sci Rep, 2020 Mar 16. PMID 32179799, Free PMC Article
    4. Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. Geisbrecht ER, et al. Dev Dyn, 2013 May. PMID 23335293, Free PMC Article
    5. From worms to humans: Understanding intestinal lipid metabolism via model organisms. Kozan DW, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 Apr. PMID 36738984, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid transport protein 3
    Names
    CG3394-PA
    CG3394-PB
    Fatp3-PA
    Fatp3-PB
    NP_611906.1
    NP_726437.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24294097..24298111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166666.2 → NP_726437.2  fatty acid transport protein 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726437.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXR7
      Related
      FBpp0072175
      Conserved Domains (2) summary
      cd05939
      Location:136 → 653
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:90 → 684
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    2. NM_138062.3 → NP_611906.1  fatty acid transport protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W185
      Related
      FBpp0072176
      Conserved Domains (2) summary
      PRK08279
      Location:64 → 658
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:110 → 627
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXR7 Q8SXR7
    Q9W185 Q9W185

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