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    pgc polar granule component [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgcprovided by FlyBase
    Official Full Name
    polar granule componentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016053
    Locus tag
    Dmel_CG32885
    See related
    AllianceGenome:FB:FBgn0016053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11296; CG32885; CR32885; Dmel\CG32885; Pgc; pgc-1; Pgc1; PGC1; pgr
    Summary
    Involved in several processes, including germ-line cyst formation; pole cell development; and regulation of gene expression. Located in P granule. Is expressed in germline cell; organism; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pgc in Genome Data Viewer
    Location:
    58D3-58D3; 2-99 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22330200..22332813)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18217705..18220318)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44756 Neighboring gene Gp150 Neighboring gene uncharacterized protein Neighboring gene Liprin-gamma Neighboring gene Type III alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Computational modeling offers new insight into Drosophila germ granule development. Valentino M, et al. Biophys J, 2022 Apr 19. PMID 35288123, Free PMC Article
    2. Distinct cis-acting elements mediate targeting and clustering of Drosophila polar granule mRNAs. Eagle WVI, et al. Development, 2018 Nov 22. PMID 30333216, Free PMC Article
    3. Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and Bombyx. Dhulkotia D, et al. Dev Genes Evol, 2000 Mar. PMID 11180815
    4. Repression of RNA polymerase II transcription by a Drosophila oligopeptide. Timinszky G, et al. PLoS One, 2008 Jun 25. PMID 18575576, Free PMC Article
    5. Maintaining sufficient nanos is a critical function for polar granule component in the specification of primordial germ cells. Deshpande G, et al. G3 (Bethesda), 2012 Nov. PMID 23173091, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Individual nos and pgc transcripts can populate the same nascent germ granule, and these first transcripts then act as seeds, recruiting additional like transcripts to form homotypic clusters.
      Title: Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules.
    2. pgc embryos have greatly reduced levels of Nos protein.
      Title: Maintaining sufficient nanos is a critical function for polar granule component in the specification of primordial germ cells.
    3. lack of pgc partly ameliorates the cellularization defect of tor mutants, thus revealing a functional antagonism between pgc and tor in the specification of germline and somatic properties.
      Title: A functional antagonism between the pgc germline repressor and torso in the development of somatic cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line cyst formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ-line cyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polar granule component
    Names
    58D gene
    CG32885-PA
    CG32885-PC
    CG32885-PD
    pgc-PA
    pgc-PC
    pgc-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22330200..22332813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103942.2 → NP_001097412.1  polar granule component, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYL7

    2. NM_001103941.2 → NP_001097411.1  polar granule component, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYL7

    3. NM_001299786.1 → NP_001286715.1  polar granule component, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286715.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYL7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYL7 A8DYL7
    Q8SZ69 Q8SZ69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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