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    Toll-7 Toll-7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Toll-7provided by FlyBase
    Official Full Name
    Toll-7provided by FlyBase
    Primary source
    FLYBASE:FBgn0034476
    Locus tag
    Dmel_CG8595
    See related
    AllianceGenome:FB:FBgn0034476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8595; CT24947; Dmel\CG8595; dTLR7; dToll7; Tl-7; toll; Toll; Toll 7; TOLL 7; toll-7; Toll7
    Summary
    Enables neurotrophin receptor activity; transmembrane signaling receptor activity; and virion binding activity. Involved in several processes, including Toll signaling pathway; regulation of defense response; and response to virus. Located in external side of plasma membrane. Is expressed in several structures, including adult head; adult olfactory antennal lobe glomerulus; cuboidal/columnar epithelium; ganglia; and head epidermis primordium. Orthologous to human CHADL (chondroadherin like) and VASN (vasorin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Toll-7 in Genome Data Viewer
    Location:
    56E4-56E4; 2-90 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19826578..19832973)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15714083..15720478)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Lysine-CTT 1-11 Neighboring gene Odorant-binding protein 56h Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44570

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity. Lamiable O, et al. J Virol, 2016 Jun 1. PMID 27009948, Free PMC Article
    2. Identification of four Drosophila Toll-related proteins as ligands for the PTP69D receptor tyrosine phosphatase. Bali N, et al. MicroPubl Biol, 2019 Sep 3. PMID 32550457, Free PMC Article
    3. Evaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus Drosophila. Díaz-Castillo C, et al. PLoS Genet, 2012 Feb. PMID 22319453, Free PMC Article
    4. Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival. Zhang J, et al. iScience, 2024 Feb 16. PMID 38292423, Free PMC Article
    5. A positional Toll receptor code directs convergent extension in Drosophila. Paré AC, et al. Nature, 2014 Nov 27. PMID 25363762, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neurotrophin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pattern recognition receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables virion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface pattern recognition receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Toll-7
    Names
    CG8595-PA
    Toll-7-PA
    Toll-like
    Toll7
    toll receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19826578..19832973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079073.3 → NP_523797.1  Toll-7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1NZA7, Q2XXU8, Q7KIN0
      Related
      FBpp0085638
      Conserved Domains (7) summary
      smart00013
      Location:796 → 830
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:716 → 772
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:1098 → 1235
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:247 → 501
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:249 → 273
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:878 → 918
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:419 → 478
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KIN0.1 Q7KIN0

    Gene LinkOut

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