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    CG4927 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4927provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034139
    Locus tag
    Dmel_CG4927
    See related
    AllianceGenome:FB:FBgn0034139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cSP42; Dmel\CG4927; SP42
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4927 in Genome Data Viewer
    Location:
    53C8-53C8; 2-80 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16572082..16574154)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12459587..12461659)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dopamine transporter Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S15 Neighboring gene Limostatin Neighboring gene antisense RNA:CR44375 Neighboring gene Cyclin-dependent kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved serine protease network mediates melanization and Toll activation in Drosophila. Shan T, et al. Sci Adv, 2023 Dec 22. PMID 38117884, Free PMC Article
    2. Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster. Huylmans AK, et al. G3 (Bethesda), 2014 Sep 22. PMID 25246242, Free PMC Article
    3. Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. Housden BE, et al. PLoS Genet, 2013. PMID 23300480, Free PMC Article
    4. The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity. Kwon SY, et al. Dev Biol, 2008 Apr 15. PMID 18334252
    5. Changes in Neuronal Signaling and Cell Stress Response Pathways are Associated with a Multigenic Response of Drosophila melanogaster to DDT Selection. Seong KM, et al. Genome Biol Evol, 2017 Dec 1. PMID 29211847, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4927-PC
    NP_001033953.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16572082..16574154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038864.2 → NP_001033953.1  uncharacterized protein Dmel_CG4927 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3U8
      Conserved Domains (2) summary
      smart00020
      Location:105 → 355
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:105 → 358
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V3U8 Q4V3U8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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