hbs hibris [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hbsprovided by FlyBase
Official Full Name: hibrisprovided by FlyBase
Primary source: FLYBASE:FBgn0287864
Locus tag: Dmel_CG7449
See related: AllianceGenome:FB:FBgn0287864
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: a69; A69; CG7449; CT22841; Dmel\CG7449; Hbs; icon
Summary: Enables cell adhesion mediator activity. Involved in several processes, including Malpighian tubule stellate cell differentiation; compound eye morphogenesis; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in adherens junction and apical plasma membrane. Colocalizes with endosome. Is expressed in several structures, including PNS glial cell; epithelium; imaginal disc; photoreceptor neurons; and presumptive wing vein. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51D8-51D8; 2-73 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15011396..15042134)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10898901..10929639)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila R8 photoreceptor cell subtype specification requires hibris.
Title: Drosophila R8 photoreceptor cell subtype specification requires hibris.
results uncover a significant but hitherto uncharacterized involvement of IRM components Hbs, Kirre, and specially Rst in ovarian development
Title: Expression of Hbs, Kirre, and Rst during Drosophila ovarian development.
the roles of Rst, Hbs, Kirre and SNS in the spacing of bristles of the anterior wing margin, are explored.
Title: The Cell Adhesion Molecules Roughest, Hibris, Kin of Irre and Sticks and Stones Are Required for Long Range Spacing of the Drosophila Wing Disc Sensory Sensilla.
Cindr recapitulates both proposed functions of its mammalian orthologs Cd2ap and Cin85: targeting the IgCAMs Rst and Hbs for endocytosis and stabilizing these heterophilic IgCAM complexes.
Title: Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog.
Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
Title: Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
identified two cell-adhesion molecules: Hibris, which is expressed in post-mitotic lamina precursor cells; and Roughest, which is expressed on retinal axons.
Title: Recognition of pre- and postsynaptic neurons via nephrin/NEPH1 homologs is a basis for the formation of the Drosophila retinotopic map.
The work indicates hbs contributes to the remodeling of cell contacts and cell shapes throughout development.
Title: Dynamic cell shapes and contacts in the developing Drosophila retina are regulated by the Ig cell adhesion protein hibris.
sns and hbs function redundantly in the formation of several muscle precursors, and loss of one copy of sns enhances the myoblast fusion phenotype of hbs mutants
Title: The immunoglobulin superfamily member Hbs functions redundantly with Sns in interactions between founder and fusion-competent myoblasts.
hibris function is not essential for prohemocyte migration out of the procephalic mesoderm NOR maintenance of Serpent expression in prohemocytes.
Title: Serpent and a hibris reporter are co-expressed in migrating cells during Drosophila hematopoiesis and Malpighian tubule formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2271 (e-PCR)
- UniSTS:5053

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule stellate cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in Malpighian tubule stellate cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of striated muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of striated muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hibris

Names: A69; CG7449-PA; CG7449-PB; CG7449-PC; hbs-PA; hbs-PB; hbs-PC; inappropriate contact; inappropriate contacts

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15011396..15042134

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299510.1 → NP_001286439.1 hibris, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286439.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9X4, Q9U3Y6, Q9V787

Conserved Domains (6) summary

cd00096
Location:852 → 928

Ig; Immunoglobulin domain

smart00408
Location:668 → 725

IGc2; Immunoglobulin C-2 Type

smart00410
Location:45 → 137

IG_like; Immunoglobulin like

cd00063
Location:935 → 1017

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:644 → 735

I-set; Immunoglobulin I-set domain

cl11960
Location:153 → 231

Ig; Immunoglobulin domain
NM_176175.2 → NP_788355.1 hibris, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788355.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9X4, Q9U3Y6, Q9V787

Related

FBpp0086545

Conserved Domains (6) summary

cd00096
Location:852 → 928

Ig; Immunoglobulin domain

smart00408
Location:668 → 725

IGc2; Immunoglobulin C-2 Type

smart00410
Location:45 → 137

IG_like; Immunoglobulin like

cd00063
Location:935 → 1017

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:644 → 735

I-set; Immunoglobulin I-set domain

cl11960
Location:153 → 231

Ig; Immunoglobulin domain
NM_079963.4 → NP_524702.3 hibris, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524702.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8MRA3, Q9U3Y6, Q9V787

Related

FBpp0086544

Conserved Domains (6) summary

cd00096
Location:852 → 928

Ig; Immunoglobulin domain

smart00408
Location:668 → 725

IGc2; Immunoglobulin C-2 Type

smart00410
Location:45 → 137

IG_like; Immunoglobulin like

cd00063
Location:935 → 1017

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:644 → 735

I-set; Immunoglobulin I-set domain

cl11960
Location:153 → 231

Ig; Immunoglobulin domain