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    Cyp6t3 Cytochrome P450 6t3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6t3provided by FlyBase
    Official Full Name
    Cytochrome P450 6t3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033697
    Locus tag
    Dmel_CG8457
    See related
    AllianceGenome:FB:FBgn0033697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6t3; bb; CG8457; cyp6t3; Cyp6T3; Dmel\CG8457
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in ecdysone biosynthetic process and regulation of developmental growth. Is expressed in corpus allatum and prothoracic gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6t3 in Genome Data Viewer
    Location:
    48E7-48E8; 2-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12190682..12192436)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8078187..8079941)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Small ribonucleoprotein particle protein SmF Neighboring gene Cytochrome P450 6g1 Neighboring gene Cytochrome P450 6g2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytochrome P450 Cyp6t3 is not required for ecdysone biosynthesis in Drosophila melanogaster. Shimell M, et al. MicroPubl Biol, 2022. PMID 35991292, Free PMC Article
    2. Multiple P450s and Variation in Neuronal Genes Underpins the Response to the Insecticide Imidacloprid in a Population of Drosophila melanogaster. Denecke S, et al. Sci Rep, 2017 Sep 12. PMID 28900129, Free PMC Article
    3. Characterization of candidate intermediates in the Black Box of the ecdysone biosynthetic pathway in Drosophila melanogaster: Evaluation of molting activities on ecdysteroid-defective larvae. Saito J, et al. J Insect Physiol, 2016 Oct-Nov. PMID 27662806
    4. Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression. Daborn PJ, et al. Insect Biochem Mol Biol, 2007 May. PMID 17456446
    5. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Brandt A, et al. Insect Mol Biol, 2002 Aug. PMID 12144699

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insecticide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to DDT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 6t3
    Names
    CG8457-PA
    Cyp6t3-PA
    NP_610745.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12190682..12192436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136901.2 → NP_610745.1  cytochrome P450 6t3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610745.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V676
      UniProtKB/TrEMBL
      L0CR27
      Related
      FBpp0087101
      Conserved Domains (1) summary
      cl12078
      Location:34 → 486
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V676.1 Q9V676

    Gene LinkOut

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