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    Ntmt N-terminal methyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ntmtprovided by FlyBase
    Official Full Name
    N-terminal methyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033457
    Locus tag
    Dmel_CG1675
    See related
    AllianceGenome:FB:FBgn0033457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1675; Dmel\CG1675; dNTMT
    Summary
    Enables N-terminal protein N-methyltransferase activity and histone methyltransferase activity. Located in nucleus. Is expressed in organism. Orthologous to several human genes including NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ntmt in Genome Data Viewer
    Location:
    46B4-46B4; 2-61 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9865632..9867051)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5753137..5754189)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Pyruvate carboxylase Neighboring gene antisense RNA:CR44293 Neighboring gene uncharacterized protein Neighboring gene pendolino Neighboring gene long non-coding RNA:CR45138 Neighboring gene Linking immunity and metabolism

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster. Villar-Garea A, et al. Nucleic Acids Res, 2012 Feb. PMID 22053083, Free PMC Article
    2. Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling. Navarro-Costa P, et al. Nat Commun, 2016 Aug 10. PMID 27507044, Free PMC Article
    3. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Choksi SP, et al. Dev Cell, 2006 Dec. PMID 17141154
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-terminal protein N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-terminal protein N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-terminal methyltransferase
    Names
    CG1675-PA
    CG1675-PB
    Ntmt-PA
    Ntmt-PB
    NP_001350855.1
    NP_610528.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9865632..9867051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363929.1 → NP_001350855.1  N-terminal methyltransferase, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NN40
      UniProtKB/TrEMBL
      A0A384ZCM4
      Conserved Domains (1) summary
      cl17173
      Location:59 → 271
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_136684.3 → NP_610528.1  N-terminal methyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NN40
      UniProtKB/TrEMBL
      A0A384ZCM4
      Related
      FBpp0087463
      Conserved Domains (1) summary
      cl17173
      Location:59 → 271
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A384ZCM4 A0A384ZCM4
    Q6NN40.1 Q6NN40

    Gene LinkOut

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