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    CG6724 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6724provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032298
    Locus tag
    Dmel_CG6724
    See related
    AllianceGenome:FB:FBgn0032298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6724
    Summary
    Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytosol and plasma membrane. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult neuromere; larval muscle cell; and mesoderm. Orthologous to human WDR12 (WD repeat domain 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6724 in Genome Data Viewer
    Location:
    32A5-32A5; 2-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10768234..10769952, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10768234..10769952, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquitin conjugating enzyme 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44582

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mes2, a MADF-containing transcription factor essential for Drosophila development. Zimmermann G, et al. Dev Dyn, 2006 Dec. PMID 17029287
    2. The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. Hull R, et al. Int J Mol Sci, 2015 May 6. PMID 25955646, Free PMC Article
    3. Functional genomics identifies TOR-regulated genes that control growth and division. Guertin DA, et al. Curr Biol, 2006 May 23. PMID 16713952
    4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
    5. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PeBoW complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6724-PA
    CG6724-PB
    ribosome biogenesis protein WDR12 homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10768234..10769952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273434.1 → NP_001260363.1  uncharacterized protein Dmel_CG6724, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB96
      Conserved Domains (4) summary
      COG2319
      Location:105 → 409
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:105 → 406
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:10 → 75
      NLE; NLE (NUC135) domain
      sd00039
      Location:198 → 248
      7WD40; WD40 repeat [structural motif]

    2. NM_135608.3 → NP_609452.1  uncharacterized protein Dmel_CG6724, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VKQ3
      Related
      FBpp0079780
      Conserved Domains (4) summary
      COG2319
      Location:105 → 411
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:105 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:10 → 75
      NLE; NLE (NUC135) domain
      sd00039
      Location:198 → 250
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB96 M9PB96
    Q9VKQ3.1 Q9VKQ3

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