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    DIP-zeta Dpr-interacting protein zeta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIP-zetaprovided by FlyBase
    Official Full Name
    Dpr-interacting protein zetaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051708
    Locus tag
    Dmel_CG31708
    See related
    AllianceGenome:FB:FBgn0051708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    31708; CG13103; CG13104; CG13105; CG31708; CT32337; CT32338; DIPzeta; Dmel\CG31708
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in proximal medullary amacrine neuron Pm2; transmedullary Y neuron TmY10; and transmedullary neuron Tm20. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DIP-zeta in Genome Data Viewer
    Location:
    29F8-30A1; 2-35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9051631..9071164, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9051631..9071164, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rcd-1 related Neighboring gene long non-coding RNA:CR44352 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44483 Neighboring gene uncharacterized protein Neighboring gene Toll-4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article
    2. Classifying Protein-Protein Binding Affinity with Free-Energy Calculations and Machine Learning Approaches. Goulard Coderc de Lacam E, et al. J Chem Inf Model, 2024 Feb 12. PMID 38272021
    3. Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. Baker BM, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34074789, Free PMC Article
    4. Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. Barish S, et al. PLoS Genet, 2018 Aug. PMID 30102700, Free PMC Article
    5. Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons. Wang Y, et al. Development, 2022 May 15. PMID 35502740, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dpr-interacting protein zeta
    Names
    CG31708-PA
    CG31708-PB
    CG31708-PC
    DIP-zeta-PA
    DIP-zeta-PB
    DIP-zeta-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9051631..9071164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201815.2 → NP_001188744.1  Dpr-interacting protein zeta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSH3, Q6NNU3
      Conserved Domains (5) summary
      cd00096
      Location:130 → 200
      Ig; Immunoglobulin domain
      smart00408
      Location:233 → 298
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:120 → 216
      IG_like; Immunoglobulin like
      pfam07679
      Location:226 → 310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:313 → 410
      Ig; Immunoglobulin domain

    2. NM_164845.4 → NP_723441.2  Dpr-interacting protein zeta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723441.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNU3, Q9VLF0
      Related
      FBpp0079378
      Conserved Domains (5) summary
      cd00096
      Location:130 → 200
      Ig; Immunoglobulin domain
      smart00408
      Location:233 → 298
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:120 → 216
      IG_like; Immunoglobulin like
      pfam07679
      Location:226 → 310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:313 → 410
      Ig; Immunoglobulin domain

    3. NM_164846.4 → NP_723442.2  Dpr-interacting protein zeta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723442.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNU3, Q9VLF0
      Related
      FBpp0079377
      Conserved Domains (5) summary
      cd00096
      Location:130 → 200
      Ig; Immunoglobulin domain
      smart00408
      Location:233 → 298
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:120 → 216
      IG_like; Immunoglobulin like
      pfam07679
      Location:226 → 310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:313 → 410
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSH3 M9MSH3
    Q9VLF0 Q9VLF0

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