Rab3GAP1 RAB3 GTPase activating protein subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab3GAP1provided by FlyBase
Official Full Name: RAB3 GTPase activating protein subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0051935
Locus tag: Dmel_CG31935
See related: AllianceGenome:FB:FBgn0051935
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10870; CG31935; CG7373; Dmel\CG31935
Summary: Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in macroautophagy. Predicted to be located in endoplasmic reticulum tubular network. Predicted to be part of protein-containing complex. Used to study Warburg micro syndrome. Human ortholog(s) of this gene implicated in Warburg micro syndrome 1. Orthologous to human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1594822..1611157, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1594822..1611157, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in establishment of protein localization to endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endoplasmic reticulum tubular network organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium ion-dependent exocytosis of neurotransmitter	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of short-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum tubular network	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

Names: CG31935-PA; RAB3 GTPase activating protein catalytic subunit 1; Rab3GAP1-PA

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