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    Nep3 Neprilysin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nep3provided by FlyBase
    Official Full Name
    Neprilysin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031081
    Locus tag
    Dmel_CG9565
    See related
    AllianceGenome:FB:FBgn0031081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CEC; CG9565; Dmel\CG9565; DmeNEP3; dNEP3; nep3; NEP3
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult brain; adult head; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to several human genes including ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nep3 in Genome Data Viewer
    Location:
    19A3-19A3; 1-64 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19961297..19969323)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19855330..19863356)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene leaky Neighboring gene Dopamine 2-like receptor Neighboring gene transfer RNA:Proline-CGG 1-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P. Chen AY, et al. Neurobiol Dis, 2018 Jun. PMID 29524599
    2. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. Turner AJ, et al. Bioessays, 2001 Mar. PMID 11223883
    3. Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory. Turrel O, et al. J Neurosci, 2016 Sep 14. PMID 27629706, Free PMC Article
    4. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model. Sun ZD, et al. Neural Regen Res, 2022 Oct. PMID 35259851, Free PMC Article
    5. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. Iijima-Ando K, et al. J Biol Chem, 2008 Jul 4. PMID 18463098, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neprilysin 3
    Names
    CG9565-PA
    CG9565-PB
    CG9565-PC
    Nep3-PA
    Nep3-PB
    Nep3-PC
    NP_001245775.1
    NP_001245776.1
    NP_523417.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19961297..19969323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258847.2 → NP_001245776.1  neprilysin 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWS1, Q9W5Y0
      Conserved Domains (1) summary
      cd08662
      Location:123 → 784
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    2. NM_078693.3 → NP_523417.2  neprilysin 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523417.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWS1, Q9W5Y0
      Related
      FBpp0070000
      Conserved Domains (1) summary
      cd08662
      Location:123 → 784
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    3. NM_001258846.1 → NP_001245775.1  neprilysin 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWS1, Q9W5Y0
      Conserved Domains (1) summary
      cd08662
      Location:123 → 784
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W5Y0.2 Q9W5Y0

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