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    CG7378 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7378provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030976
    Locus tag
    Dmel_CG7378
    See related
    AllianceGenome:FB:FBgn0030976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH25447; Dmel\CG7378; MKP-like
    Summary
    Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in adult head and adult heart. Orthologous to several human genes including DUSP13B (dual specificity phosphatase 13B); DUSP26 (dual specificity phosphatase 26); and DUSP29 (dual specificity phosphatase 29). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7378 in Genome Data Viewer
    Location:
    17F2-17F3; 1-61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18900410..18911843)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18794443..18805876)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Fl(2)d-associated complex component Neighboring gene Succinate dehydrogenase, subunit B (iron-sulfur)-like Neighboring gene long non-coding RNA:CR44708 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles for RNA export factor, Nxt1, in ensuring muscle integrity and normal RNA expression in Drosophila. van der Graaf K, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561245, Free PMC Article
    2. Direct Testing for Allele-Specific Expression Differences Between Conditions. León-Novelo L, et al. G3 (Bethesda), 2018 Feb 2. PMID 29167272, Free PMC Article
    3. A Hopscotch-chromatin connection. Betz A, et al. Nat Genet, 2006 Sep. PMID 16941005
    4. A Drosophila-centric view of protein tyrosine phosphatases. Hatzihristidis T, et al. FEBS Lett, 2015 Apr 13. PMID 25771859
    5. RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells. Wheeler DB, et al. Nat Methods, 2004 Nov. PMID 15782175

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7378-PA
    CG7378-PB
    CG7378-PC
    MKP-like
    NP_001097027.1
    NP_001285421.1
    NP_573341.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18900410..18911843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298492.1 → NP_001285421.1  uncharacterized protein Dmel_CG7378, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXF8, X2JEB8
      Conserved Domains (1) summary
      cd14515
      Location:71 → 227
      DUSP3-like; dual specificity protein phosphatases 3, 13, 26, 27, and similar domains

    2. NM_001103557.2 → NP_001097027.1  uncharacterized protein Dmel_CG7378, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUQ2, Q8SXF8
      Conserved Domains (1) summary
      cd14515
      Location:71 → 218
      DUSP3-like; dual specificity protein phosphatases 3, 13, 26, 27, and similar domains

    3. NM_133113.2 → NP_573341.1  uncharacterized protein Dmel_CG7378, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXF8, Q9VWN2
      Related
      FBpp0074420
      Conserved Domains (1) summary
      cd14515
      Location:51 → 198
      DUSP3-like; dual specificity protein phosphatases 3, 13, 26, 27, and similar domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUQ2 A8JUQ2
    Q8SXF8 Q8SXF8
    Q9VWN2 Q9VWN2
    X2JEB8 X2JEB8

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