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    CG9673 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9673provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030775
    Locus tag
    Dmel_CG9673
    See related
    AllianceGenome:FB:FBgn0030775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9673; SPH81
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human PRSS54 (serine protease 54). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9673 in Genome Data Viewer
    Location:
    15A2-15A3; 1-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16702786..16703884, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16596819..16597917, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spheroide Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The serine protease homolog spheroide is involved in sensing of pathogenic Gram-positive bacteria. Patrnogic J, et al. PLoS One, 2017. PMID 29211760, Free PMC Article
    2. Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Blount JR, et al. Biol Open, 2019 May 30. PMID 31097444, Free PMC Article
    3. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article
    4. Drosophila melanogaster larval hemolymph protein mapping. Guedes Sde M, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680800
    5. Evolution of a cellular immune response in Drosophila: a phenotypic and genomic comparative analysis. Salazar-Jaramillo L, et al. Genome Biol Evol, 2014 Feb. PMID 24443439, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9673-PA
    CG9673-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16702786..16703884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298417.1 → NP_001285346.1  uncharacterized protein Dmel_CG9673, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXC7
      Conserved Domains (2) summary
      smart00020
      Location:28 → 256
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:29 → 259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_132921.3 → NP_573149.1  uncharacterized protein Dmel_CG9673, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXC7
      Related
      FBpp0074136
      Conserved Domains (2) summary
      smart00020
      Location:28 → 256
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:29 → 259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXC7 Q9VXC7

    Gene LinkOut

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