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    Upf2 Upf2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Upf2provided by FlyBase
    Official Full Name
    Upf2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029992
    Locus tag
    Dmel_CG2253
    See related
    AllianceGenome:FB:FBgn0029992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2253; Dmel\CG2253; smg-3; upf2; UPF2
    Summary
    Predicted to enable RNA binding activity. Involved in neuromuscular synaptic transmission; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and synapse organization. Predicted to be part of exon-exon junction complex. Predicted to be active in cytoplasm. Is expressed in adult heart. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Upf2 in Genome Data Viewer
    Location:
    7D5-7D5; 1-22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8070244..8075466, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7964277..7969499, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) homeotic Neighboring gene myospheroid Neighboring gene uncharacterized protein Neighboring gene Lipid droplet subset dehydrogenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. Ponting CP. Trends Biochem Sci, 2000 Sep. PMID 10973054
    2. Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response. Johnson JL, et al. Neuron, 2019 Nov 20. PMID 31585809, Free PMC Article
    3. Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration. Zuniga G, et al. Alzheimers Dement, 2023 Feb. PMID 35416419, Free PMC Article
    4. In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila. Chapin A, et al. G3 (Bethesda), 2014 Mar 20. PMID 24429422, Free PMC Article
    5. Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Nelson JO, et al. Genetics, 2018 Aug. PMID 29903866, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our findings indicate that impaired UPF2-dependent nonsense-mediated decay leads to neurodevelopmental dysfunction
      Title: Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response.
    2. the lethality of upf1 and upf2 mutants is not due to disrupting their roles during Nonsense-mediated RNA decay (NMD) -independent processes, but to their function in the degradation of specific mRNAs by the NMD pathway.
      Title: Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Upf2
    Names
    CG2253-PA
    Upf2-PA
    up-frameshift suppressor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8070244..8075466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132206.3 → NP_572434.1  Upf2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3L1
      Related
      FBpp0071072
      Conserved Domains (3) summary
      smart00543
      Location:518 → 701
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:716 → 934
      MIF4G; MIF4G domain
      pfam04050
      Location:980 → 1192
      Upf2; Up-frameshift suppressor 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU82 Q7YU82
    Q9W3L1 Q9W3L1

    Gene LinkOut

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