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    CG5937 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5937provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029834
    Locus tag
    Dmel_CG5937
    See related
    AllianceGenome:FB:FBgn0029834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5937
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Is expressed in adult head and spermatozoon. Orthologous to human ARFGEF3 (ARFGEF family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5937 in Genome Data Viewer
    Location:
    5D2-5D3; 1-15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6040005..6050381)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5934038..5944414)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene roughex Neighboring gene Malignant T cell amplified sequence 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth. Chang L, et al. Biol Open, 2015 Jun 26. PMID 26116655, Free PMC Article
    2. Altered levels of hsromega lncRNAs further enhance Ras signaling during ectopically activated Ras induced R7 differentiation in Drosophila. Ray M, et al. Gene Expr Patterns, 2019 Sep. PMID 31096022
    3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    4. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5937-PC
    CG5937-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6040005..6050381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132061.3 → NP_572289.2  uncharacterized protein Dmel_CG5937, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572289.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUY6, Q9W444
      Conserved Domains (2) summary
      pfam09324
      Location:1115 → 1179
      DUF1981; Domain of unknown function (DUF1981)
      cl00136
      Location:451 → 692
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    2. NM_001103418.3 → NP_001096888.2  uncharacterized protein Dmel_CG5937, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096888.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUY6, Q9W444
      Conserved Domains (2) summary
      pfam09324
      Location:1115 → 1179
      DUF1981; Domain of unknown function (DUF1981)
      cl00136
      Location:451 → 692
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W444 Q9W444

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