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    CG14630 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14630provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014903
    Locus tag
    Dmel_CG14630
    See related
    AllianceGenome:FB:FBgn0014903
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-1Eb; B; Dmel\CG14630; EG:BACR7A4.9; gamma-BBH; Tmlhe
    Summary
    Predicted to enable gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14630 in Genome Data Viewer
    Location:
    1E1-1E1; 1-0.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1031496..1033165)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (925538..927198)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene suppressor of white-apricot Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 45 Neighboring gene Ribonuclease P/MRP subunit p21 Neighboring gene long non-coding RNA:CR44779 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of a regulatory gene is programmed at the level of splicing. Chou TB, et al. EMBO J, 1987 Dec 20. PMID 2832151, Free PMC Article
    2. Molecular cloning and genetic analysis of the suppressor-of-white-apricot locus from Drosophila melanogaster. Zachar Z, et al. Mol Cell Biol, 1987 Jul. PMID 3039348, Free PMC Article
    3. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
    4. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Musselman LP, et al. Dis Model Mech, 2011 Nov. PMID 21719444, Free PMC Article
    5. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-butyrobetaine dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carnitine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14630-PA
    gamma-ButyroBetaine hydroxylase
    transcription unit B
    NP_651985.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1031496..1033165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143728.4 → NP_651985.1  uncharacterized protein Dmel_CG14630 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C5A2, Q9W5B5
      Related
      FBpp0070170
      Conserved Domains (3) summary
      cd00250
      Location:120 → 390
      CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
      TIGR02409
      Location:30 → 400
      carnitine_bodg; gamma-butyrobetaine hydroxylase
      cl01414
      Location:41 → 107
      DUF971; Protein of unknown function (DUF971)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NF72 Q9NF72
    Q9W5B5 Q9W5B5

    Gene LinkOut

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