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    kek3 kekkon 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kek3provided by FlyBase
    Official Full Name
    kekkon 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028370
    Locus tag
    Dmel_CG4192
    See related
    AllianceGenome:FB:FBgn0028370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS04862.1; CG4192; CT12629; Dmel\CG4192; kek-3
    Summary
    Predicted to be located in plasma membrane. Orthologous to human LRFN1 (leucine rich repeat and fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kek3 in Genome Data Viewer
    Location:
    35D3-35D3; 2-51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15552723..15583978)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15552723..15583978)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45728 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44865 Neighboring gene uncharacterized protein Neighboring gene Seminal metalloprotease-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
    2. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
    3. Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster. Nicol A, et al. PLoS One, 2024. PMID 39196987, Free PMC Article
    4. Epidermal growth factor receptor signaling. Bogdan S, et al. Curr Biol, 2001 Apr 17. PMID 11369216
    5. Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. Ulian-Benitez S, et al. PLoS Genet, 2017 Aug. PMID 28846707, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kekkon 3
    Names
    CG4192-PA
    CG4192-PB
    Kekkon-3
    kek3-PA
    kek3-PB
    kekkon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15552723..15583978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169515.2 → NP_001162986.1  kekkon 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V430
      Conserved Domains (6) summary
      cd00096
      Location:335 → 425
      Ig; Immunoglobulin domain
      smart00082
      Location:267 → 316
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:328 → 428
      IG_like; Immunoglobulin like
      cd00116
      Location:110 → 267
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:112 → 137
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:184 → 245
      LRR_8; Leucine rich repeat

    2. NM_078851.3 → NP_523575.1  kekkon 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V430
      Related
      FBpp0080311
      Conserved Domains (6) summary
      cd00096
      Location:335 → 425
      Ig; Immunoglobulin domain
      smart00082
      Location:267 → 316
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:328 → 428
      IG_like; Immunoglobulin like
      cd00116
      Location:110 → 267
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:112 → 137
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:184 → 245
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V430 Q9V430

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