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    CG4325 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4325provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026878
    Locus tag
    Dmel_CG4325
    See related
    AllianceGenome:FB:FBgn0026878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4325; EG:22E5.12
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in positive regulation of antibacterial peptide biosynthetic process. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4325 in Genome Data Viewer
    Location:
    2C7-2C7; 1-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2042730..2043818, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1936763..1937851, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene alpha actinin Neighboring gene mir-4954 stem loop Neighboring gene ultraspiracle Neighboring gene uncharacterized protein Neighboring gene moody Neighboring gene antisense RNA:CR44896 Neighboring gene Salt-inducible kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Bainton RJ, et al. Cell, 2005 Oct 7. PMID 16213219
    2. Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Wahlström G, et al. Mech Dev, 2006 Nov. PMID 17008069
    3. Tissue-autonomous EcR functions are required for concurrent organ morphogenesis in the Drosophila embryo. Chavoshi TM, et al. Mech Dev, 2010 May-Jun. PMID 20093179
    4. Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. Valanne S, et al. J Immunol, 2010 Jun 1. PMID 20421637
    5. Modeling spinal muscular atrophy in Drosophila. Chang HC, et al. PLoS One, 2008 Sep 15. PMID 18791638, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4325-PA
    CG4325-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2042730..2043818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272240.1 → NP_001259169.1  uncharacterized protein Dmel_CG4325, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6Q6, Q9XZS4
      Conserved Domains (2) summary
      pfam13639
      Location:8 → 49
      zf-RING_2; Ring finger domain
      cl09111
      Location:112 → 151
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. NM_130613.3 → NP_569969.1  uncharacterized protein Dmel_CG4325, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6Q6, Q9XZS4
      Related
      FBpp0070328
      Conserved Domains (2) summary
      pfam13639
      Location:8 → 49
      zf-RING_2; Ring finger domain
      cl09111
      Location:112 → 151
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZS4 Q9XZS4

    Gene LinkOut

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