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    Irp-1B Iron regulatory protein 1B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Irp-1Bprovided by FlyBase
    Official Full Name
    Iron regulatory protein 1Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024957
    Locus tag
    Dmel_CG6342
    See related
    AllianceGenome:FB:FBgn0024957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    144037_at; C-Acon; cAcon; cACON; CG6342; dIRP; Dmel\CG6342; IRF; IRP; IRP-1; irp-1B; IRP-1B; IRP1; irp1B; IRP1B
    Summary
    Enables aconitate hydratase activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Located in cytosol and nucleus. Is expressed in adult heart and organism. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including ACO1 (aconitase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Irp-1B in Genome Data Viewer
    Location:
    86B4-86B4; 3-49 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10408618..10412869, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6234340..6238591, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-994 stem loop Neighboring gene mir-318 stem loop Neighboring gene Rrp46 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using PRINS for gene mapping in polytene chromosomes. Gu HF, et al. Chromosome Res, 1997 Nov. PMID 9421263
    2. The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Rothenberger S, et al. Nucleic Acids Res, 1990 Mar 11. PMID 2157191, Free PMC Article
    3. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Gray NK, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643505, Free PMC Article
    4. Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans. Muckenthaler M, et al. Eur J Biochem, 1998 Jun 1. PMID 9660175
    5. Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant. Surdej P, et al. Insect Biochem Mol Biol, 2008 Sep. PMID 18675912

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulating Irp-1B in neurons of single-housed Abeta42 expressing and control flies rescued both survival and motor performance deficits. Authors provide novel evidence that increased cerebral expression of Irp-1B may underlie worsened behavioral outcome in socially deprived flies and can additionally modulate AD-like phenotypes.
      Title: Decreased cerebral Irp-1B limits impact of social isolation in wild type and Alzheimer's disease modeled in Drosophila melanogaster.
    2. muscle-specific overexpression of IRP-1A, but not of IRP-1B, resulted in pre-adult lethality, underscoring the importance of the biochemical difference between the two proteins;only IRP-1A can bind to iron-responsive elements
      Title: Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aconitate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT enables iron-responsive element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in citrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iron regulatory protein 1B
    Names
    CG6342-PA
    Irp-1B-PA
    c-aconitase
    cytoplasmic aconitase
    cytosolic aconitase
    iron regulatory factor
    iron regulatory protein
    NP_524303.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10408618..10412869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079579.3 → NP_524303.2  iron regulatory protein 1B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524303.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFX2, Q9VGZ3
      Related
      FBpp0081736
      Conserved Domains (3) summary
      cd01586
      Location:86 → 576
      AcnA_IRP; Aconitase A catalytic domain
      cd01580
      Location:680 → 849
      AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
      PTZ00092
      Location:1 → 899
      PTZ00092; aconitate hydratase-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76935 O76935
    Q9NFX2 Q9NFX2
    Q9VGZ3 Q9VGZ3

    Gene LinkOut

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