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    Ras64B Ras oncogene at 64B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ras64Bprovided by FlyBase
    Official Full Name
    Ras oncogene at 64Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003206
    Locus tag
    Dmel_CG1167
    See related
    AllianceGenome:FB:FBgn0003206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE36103; c-ras2; C-ras2; CG1167; D-ras-2; D-ras2; Dm-ras-64B; Dmel\CG1167; Dmras64B; Dras2; DRas2; Dras64B; ras; Ras; RAS; ras-2; ras2; Ras2; RAS2; RAS64B
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including female germline cell; ganglia; gonad; imaginal disc; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to several human genes including RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ras64B in Genome Data Viewer
    Location:
    64A7-64A7; 3-10 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4139076..4141398)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4139076..4141398)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Replication factor C subunit 4 Neighboring gene Ras opposite Neighboring gene Adipokinetic hormone Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and developmental expression of a Drosophila ras oncogene. Mozer B, et al. Mol Cell Biol, 1985 Apr. PMID 3921827, Free PMC Article
    2. Conserved cis-elements bind a protein complex that regulates Drosophila ras2/rop bidirectional expression. Lightfoot K, et al. Br J Cancer, 1994 Feb. PMID 8297724, Free PMC Article
    3. Interaction of mRNA with the C-Terminal Domain of PCID2, a Subunit of the TREX-2 Complex, Is Required for Its Export from the Nucleus to the Cytoplasm in Drosophila melanogaster. Vdovina YA, et al. Dokl Biochem Biophys, 2023 Dec. PMID 38066318, Free PMC Article
    4. Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex. Kurshakova MM, et al. Dokl Biochem Biophys, 2024 Oct. PMID 39196529
    5. The Drosophila Ras2 and Rop gene pair: a dual homology with a yeast Ras-like gene and a suppressor of its loss-of-function phenotype. Salzberg A, et al. Development, 1993 Apr. PMID 8404533

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex.
      Title: Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex.
    2. Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability.
      Title: Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability.
    3. According to Bridges' map, all three bands (Dras1, Dras2, Dras3) were mapped to regions 85D, 64B, and 62B of chromosome 3. Among them, only Drasl has a common origin with ras genes of mammals.
      Title: [Universal intracellular transducer RAS and its role in the development of Drosophila].
    4. Our evidence suggests that tumors can evolve into malignancy through oncogenic Ras activation and the hijacking of TNF signaling.
      Title: Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras oncogene at 64B
    Names
    CG1167-PA
    Ras64B-PA
    ras oncogene
    small GTP binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4139076..4141398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079193.4 → NP_523917.2  Ras oncogene at 64B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523917.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04388, Q9VZH7
      Related
      FBpp0073068
      Conserved Domains (1) summary
      cd04145
      Location:4 → 167
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04388.2 P04388

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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