Ras85D Ras oncogene at 85D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ras85Dprovided by FlyBase
Official Full Name: Ras oncogene at 85Dprovided by FlyBase
Primary source: FLYBASE:FBgn0003205
Locus tag: Dmel_CG9375
See related: AllianceGenome:FB:FBgn0003205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: C-ras1; CG9375; D-Ras; D-ras-1; D-ras1; D-Ras1; Dm Ras1; Dmel\CG9375; Dmras85D; dRas; Dras; DRas; dras1; dRas1; dRAS1; Dras1; DRAS1; dRas85D; Dras85D; DRas85D/Ras; E(faf); E(sev)3C; EC3-3; EK3-4; fs(3)05703; l(3)06677; l(3)s1747; P08646; p21[Ras1]; ras; Ras; RAS; ras 1; Ras 85D; Ras-1; Ras.85D; ras1; Ras1; RAS1; Ras1/RAs85D; Ras185D; Ras85; ras85B; ras85D; Ras85d; RAS85D; Ras85DNt; RasI; Rasv12; RasV12; ras[V12]; Ras[V12]; RTK; S35097; Su(tor)3-2
Summary: Enables G protein activity and protein serine/threonine kinase activator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; instar larval or pupal development; and respiratory system development. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; brain; germline cell; and imaginal disc. Used to study Noonan syndrome 3; cancer (multiple); and heart disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); hematologic cancer (multiple); and high grade glioma (multiple). Orthologous to several human genes including HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85D19-85D19; 3-48 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9510561..9513067, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5336283..5338789, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Misshapen Disruption Cooperates with Ras(V12) to Drive Tumorigenesis.
Title: Misshapen Disruption Cooperates with Ras(V12) to Drive Tumorigenesis.
Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage.
Title: Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage.
Ras knockdown enhanced the consolidation of anesthesia-resistant memory.
Title: Ras acts as a molecular switch between two forms of consolidated memory in Drosophila.
In conclusion, Ras(V12)-modified caspases initiate a feedback amplification loop involving tumorous epithelial cells and macrophage-like immune cells that is necessary for uncontrolled tumor growth and invasive behavior.
Title: Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila.
Thus, our current work provides a novel mechanism of pupal size determination by microRNAs during Drosophila melanogaster metamorphosis.
Title: miR-11 regulates pupal size of Drosophila melanogaster via directly targeting Ras85D.
Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth.
Title: Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth.
Data indicate that dysfunction of Rab5 leads to cell-autonomous accumulation of a TNF homolog Eiger, and causes activation of Ras signaling.
Title: Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila.
According to Bridges' map, all three bands (Dras1, Dras2, Dras3) were mapped to regions 85D, 64B, and 62B of chromosome 3. Among them, only Drasl has a common origin with ras genes of mammals.
Title: [Universal intracellular transducer RAS and its role in the development of Drosophila].
RhoGEF2 also cooperates with an activated allele of a downstream effector of Ras, Raf (Raf(GOF)).
Title: In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling.
Inhibition of Ras1 signaling leads to reduced Appl expression, whereas constitutive activation drives ectopic Appl expression.
Title: β amyloid protein precursor-like (Appl) is a Ras1/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein activity	IDA Inferred from Direct Assay more info	PubMed
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R7 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Ras protein signal transduction	HGI more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chorion-containing eggshell pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, spreading of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc proximal/distal pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in lymph gland crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hemocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sevenless signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal region determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of epidermal cells	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ras oncogene at 85D

Names: CG9375-PA; Ras GTPase; Ras oncogene at 85B; Ras1; Ras85D-PA; enhancer of faf

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9510561..9513067 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057351.5 → NP_476699.1 Ras oncogene at 85D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476699.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08646, Q9V448

Related

FBpp0081600

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B