D Dichaete [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dprovided by FlyBase
Official Full Name: Dichaeteprovided by FlyBase
Primary source: FLYBASE:FBgn0000411
Locus tag: Dmel_CG5893
See related: AllianceGenome:FB:FBgn0000411
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5893; d; Dic; DM10; DM23; DM33; DM36; DM63; Dmel\CG5893; fish; l(3)LG9; loD; Sox B2-1; Sox70; SOX70; Sox70D; SOX70D; SOXB2.1; SOXDP; Sry-rDM10; Sry-rDM23; Sry-rDM33; Sry-rDM36; Sry-rDM63
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and nucleic acid binding activity. Involved in several processes, including nervous system development; regionalization; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; glial cell; gut section; and segmentally-repeated neuroblast. Human ortholog(s) of this gene implicated in X-linked panhypopituitarism. Orthologous to human SOX3 (SRY-box transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 70D3-70D3; 3-42 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14175610..14178620, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14168710..14171720, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
Title: Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
The authors propose that Osa and its target genes opa and D form an incoherent feedforward loop (FFL) and a new mechanism allowing the successive expression of temporal identities in intermediate neural progenitors.
Title: The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop.
Analysis of the functional relationship between SoxNeuro and Dichaete uncovers evidence for redundant and independent functions for each protein, along with unexpected examples of compensation and interdependency.
Title: SoxNeuro orchestrates central nervous system specification and differentiation in Drosophila and is only partially redundant with Dichaete.
Dichaete acts as a transcriptional hub, controlling multiple regulatory pathways during CNS development.
Title: The role of Dichaete in transcriptional regulation during Drosophila embryonic development.
the early neurectoderm we implicate Dichaete in the lateral inhibition pathway and show that Dichaete acts to repress the proneural gene asense
Title: Identifying targets of the Sox domain protein Dichaete in the Drosophila CNS via targeted expression of dominant negative proteins.
These results suggest noncell autonomous functions of Dichaete in projection neuron differentiation as well as a potential role for Dichaete-expressing local interneurons
Title: The sox gene Dichaete is expressed in local interneurons and functions in development of the Drosophila adult olfactory circuit.
Data show that Dichaete appears to be a novel phosphorylation substrate for Pelle and may function in a Pelle-dependent signaling pathway during oogenesis.
Title: Drosophila Pelle phosphorylates Dichaete protein and influences its subcellular distribution in developing oocytes.
The expression of svb in a discreet domain is resolved at the level of SoxN and Dichaete.
Title: The Drosophila HMG-domain proteins SoxNeuro and Dichaete direct trichome formation via the activation of shavenbaby and the restriction of Wingless pathway activity.
Evidence for differential and redundant function of the Sox genes during CNS development in Drosophila
Title: Evidence for differential and redundant function of the Sox genes Dichaete and SoxN during CNS development in Drosophila.
Results show that expression of Dichaete protein is detected in the developing oocyte during early to mid stages of oogenesis, exhibits cytoplasmic distribution, and plays a direct post-transcriptional role in regulating RNA functions.
Title: Maternal expression and function of the Drosophila sox gene Dichaete during oogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization involved in pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in post-embryonic appendage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: dichaete

Names: CG5893-PA; CG5893-PB; CG5893-PC; CG5893-PD; D-PA; D-PB; D-PC; D-PD; Fish-Hook; Sox box protein 70D; Sry-related DM10; Sry-related DM23; Sry-related DM33; Sry-related DM36; Sry-related DM63; dicheate; fish hook; lethal of dichaete

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14175610..14178620 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079342.3 → NP_524066.1 dichaete, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524066.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2VED6, Q24533, Q8MSP8, Q9VUD4

UniProtKB/TrEMBL

M9PFL2

Related

FBpp0075488

Conserved Domains (1) summary

cd01388
Location:141 → 212

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001274902.1 → NP_001261831.1 dichaete, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261831.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2VED6, Q24533, Q8MSP8, Q9VUD4

UniProtKB/TrEMBL

M9PFL2

Conserved Domains (1) summary

cd01388
Location:141 → 212

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001274903.1 → NP_001261832.1 dichaete, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261832.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2VED6, Q24533, Q8MSP8, Q9VUD4

UniProtKB/TrEMBL

M9PFL2

Conserved Domains (1) summary

cd01388
Location:141 → 212

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001274901.1 → NP_001261830.1 dichaete, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261830.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2VED6, Q24533, Q8MSP8, Q9VUD4

UniProtKB/TrEMBL

M9PFL2

Conserved Domains (1) summary

cd01388
Location:141 → 212

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...