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    Ntan1 N-terminal amidohydrolase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37147, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ntan1provided by FlyBase
    Official Full Name
    N-terminal amidohydrolase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034371
    Locus tag
    Dmel_CG5473
    See related
    AllianceGenome:FB:FBgn0034371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH24992; CG5473; dm-ntan1; Dmel\CG5473; ntan1; NTAN1; obek; SP2637
    Summary
    Enables protein-N-terminal asparagine amidohydrolase activity. Involved in negative regulation of glial cell proliferation; positive regulation of DNA endoreduplication; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Located in nucleus. Is expressed in several structures, including antennal lobe hub; embryonic epidermis; embryonic/larval optic lobe; first optic chiasma; and glial cell. Orthologous to human NTAN1 (N-terminal asparagine amidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ntan1 in Genome Data Viewer
    Location:
    55E3-55E5; 2-86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18640862..18658222, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14528367..14545727, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-9 Neighboring gene Chemosensory protein A 56a Neighboring gene uncharacterized protein Neighboring gene GDI interacting protein 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ntan1 gene is expressed in perineural glia and neurons of adult Drosophila. Castañeda-Sampedro A, et al. Sci Rep, 2022 Aug 30. PMID 36042338, Free PMC Article
    2. Borderless regulates glial extension and axon ensheathment. Cameron S, et al. Dev Biol, 2016 Jun 15. PMID 27131624
    3. Organization of antennal lobe-associated neurons in adult Drosophila melanogaster brain. Tanaka NK, et al. J Comp Neurol, 2012 Dec 15. PMID 22592945
    4. A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis. Wang Z, et al. Elife, 2017 Dec 12. PMID 29231806, Free PMC Article
    5. Organization and metamorphosis of glia in the Drosophila visual system. Edwards TN, et al. J Comp Neurol, 2012 Jul 1. PMID 22351615

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In glia, Obek counteracts fibroblast growth factor and Hippo signaling to differentially affect cell growth and number.
      Title: Differential expression of Öbek controls ploidy in the Drosophila blood-brain barrier.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-N-terminal asparagine amidohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-N-terminal asparagine amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-N-terminal asparagine amidohydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-terminal amidohydrolase 1
    Names
    CG5473-PA
    CG5473-PB
    CG5473-PC
    CG5473-PD
    N-terminal amidohydrolase
    Nt-amidase
    Ntan1-PA
    Ntan1-PB
    Ntan1-PC
    Ntan1-PD
    SP2637
    NP_001163199.1
    NP_001163200.1
    NP_611355.2
    NP_725811.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18640862..18658222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169728.2 → NP_001163199.1  N-terminal amidohydrolase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KIS4
      Conserved Domains (1) summary
      pfam14736
      Location:40 → 306
      N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

    2. NM_001169729.2 → NP_001163200.1  N-terminal amidohydrolase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KIS4
      Conserved Domains (1) summary
      pfam14736
      Location:40 → 306
      N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

    3. NM_137511.4 → NP_611355.2  N-terminal amidohydrolase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611355.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSD1
      Related
      FBpp0085839
      Conserved Domains (1) summary
      pfam14736
      Location:40 → 306
      N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

    4. NM_166300.3 → NP_725811.1  N-terminal amidohydrolase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSD1
      Related
      FBpp0085840
      Conserved Domains (1) summary
      pfam14736
      Location:40 → 306
      N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KIS4 Q7KIS4
    Q8MSD1 Q8MSD1

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